MediAim

Partners

The MediAim consortium comprises three institutes: the Institute for Clinical and Experimental Medicine, the Institute of Organic Chemistry and Biochemistry of the CAS, and the Institute of Physiology of the CAS.

Institute for Clinical and Experimental Medicine

The Institute for Clinical and Experimental Medicine (IKEM) is the only clinical center in the Czech Republic combining the full spectrum of therapies for diabetes and cardiovascular diseases, from various types of pharmacotherapies and standard invasive interventions to transplantation therapy for organ failure (heart, liver, kidneys, pancreas, and pancreatic islets). Intensive clinical, experimental, and translational research is conducted in each of these areas. In experimental research, IKEM primarily focuses on the study of experimental pathophysiological and physiological models pertaining to cardiovascular diseases, transplantation, diabetology, obesitology, and kidney disease. Most experimental research activities are conducted at the Experimental Medicine Centre (EMC), which also serves as a base for postgraduate studies in molecular biology and genetics, physiology and pathophysiology, biochemistry and pathobiochemistry, and metabolic disorders. In 2018, the Research, Development, and Innovation Council of the Government of the Czech Republic ranked IKEM an outstanding Class A research organization based on a new methodology known as M17+.

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Institute for Clinical and Experimental Medicine

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading research institute of European and global importance. It traditionally combines organic chemistry with fields of biology and medicine. The institute’s primary mission is the pursuit of basic research in chemical biology and medicinal chemistry, organic and materials chemistry, chemistry of natural substances, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry, and an integral part of that mission is the transfer of research results into practice. Emphasis on interdisciplinary research has given rise to a wide range of applications in medicine, pharmaceutics, and other industries and led to extensive collaboration with Gilead Sciences and the development of drugs such as Vistide, Viread, Hepsera, and Truvada. Currently, IOCB is achieving remarkable results in several areas of biomedical research, namely in the preparation of substances for potential treatment of metabolic and neurodegenerative diseases. A joint project is being undertaken with the Institute of Physiology of the Czech Academy of Sciences to pursue development of potential substances to treat metabolic syndrome, and a license agreement was signed in 2017 with Novo Nordisk, a leading pharmaceutical company in the treatment of diabetes and obesity. 

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Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Institute of Physiology of the Czech Academy of Sciences

The Institute of Physiology of the Czech Academy of Sciences (IPHYS) is a leading national biomedicine research institute. It focuses on examining basic biological mechanisms, from the molecular level to the entire body. These mechanisms play a role in the occurrence of serious diseases, namely diseases associated with ageing and obesity (neurodegenerative and cardiovascular diseases, diabetes), epilepsy, and inherited metabolic diseases. The results of the research conducted at IPHYS help improve preventive, diagnostic, and therapeutic methods in the fight against serious lifestyle diseases affecting the whole of society. Much research is conducted in collaboration with the partners of this project as well as with other institutions, and IPHYS enriches these joint efforts with its unique expertise, methods, and biomodels. The institute offers preclinical testing of potential drugs with support provided by Strategy AV21 of the Czech Academy of Sciences. It also educates university students and trains PhD students in its biomedicine programs. In 2019, IPHYS was one of the first research institutes in the Czech Republic to receive the European Commission’s prestigious HR Award for excellence in human resources management in the scientific environment. 

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Institute of Physiology of the Czech Academy of Sciences