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2025

Myšková, A., David, T., Šedinová, M., Demirci, I., Polášek, M., Kuneš, J., Maletínská, L., Sýkora, D., Kaňa, A. Liquid chromatography–inductively coupled plasma mass spectrometry analysis of peptides labelled with ClickZip mass tags. Analytica Chimica Acta. 2025, 1350(May 8), 343853. https://doi.org/10.1016/j.aca.2025.343853

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IOCB

Brejchová, K., Rahm, M., Beňová, A., Domanská, V., Reyes Gutierrez, P. E., Džubanová, M., Trubačová, R., Vondráčková, M., Čajka, T., Tencerová, M., Vrábel, M., Kuda, O. Uncovering mechanisms of thiazolidinediones on osteogenesis and adipogenesis using spatial fluxomics. Metabolism. 2025, 166(May), 156157. https://doi.org/10.1016/j.metabol.2025.156157

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IOCB

Pušnik, L., Gabor, A, Radochová, B., Janáček. J., Saudek, F., Alibegović, A., Serša, I., Cvetko, E., Umek, N., Snoj, Ž. High-Field Diffusion Tensor Imaging of Median, Tibial, and Sural Nerves in Type 2 Diabetes With Morphometric Analysis. Journal of Bioimaging. 2025, 35(11), e70025. https://doi.org/10.1111/jon.70025

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IKEM

Mráziková, L., Hojná, S., Shánělová, A., Železná, B., Kuneš, J., Maletínská, L. Anti-inflammatory effects of palm¹¹-PrRP31 in a rat model of lipopolysaccharide-induced acute inflammation. Journal of Molecular Endocrinology. 2025, 74(3), e240090. https://doi.org/10.1530/JME-24-0090

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IOCB

Mengr, A., Šmotková, Z., Pačesová, A., Železná, B., Kuneš, J., Maletínská, L. Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease. Neuroimmune Pharmacology. 2025, 20(Feb 11), 18. https://doi.org/10.1007/s11481-025-10174-w

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Peteláková, M., Neprašová, B., Šmotková, Z., Myšková, A., Holá, L., Petelák, A., Áčová, A., Cantel, S., Fehrentz, J. A., Sýkora, D., Kuneš, J., Železná, B., Maletínská, L. Simultaneous treatment with palm-LEAP2(1–14) and feeding high-fat diet attenuates liver lipid metabolism but not obesity: Sign of selective resistance to palm-LEAP2(1–14). Molecular and Cellular Endocrinology. 2025, 597 (Feb 1), 112442. https://doi.org/10.1016/j.mce.2024.112442

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IOCB

Pušnik, L., Radochová, B., Janáček, J., Saudek, F., Serša, I., Cvetko, E., Umek, N., Snoj, Ž. Fascicle differentiation of upper extremity nerves on high-resolution ultrasound with multimodal microscopic verification. Scientific Reports. 2025, 15(Jan 2), 557. https://doi.org/10.1038/s41598-024-84396-y

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IKEM

Melenovský, V., Hošková, E., Velebová, K., Veleba, J., Borlaug, B. A., Beneš, J., Kuda, O., Čajka, T., Segeťová, M., Thieme, L., Kopecký Jr., J., Kopecký, J., Pelikánová, T., Haluzík, M., Hill, M., Kahleová, H. Metformin Improves Glycemic Control and Postprandial Metabolism and Enhances Postprandial Glucagon-Like Peptide 1 Secretion in Patients With Type 2 Diabetes and Heart Failure: A Randomized, Double-Blind, Placebo-Controlled Trial. Clinical Diabetes. 2025, 43(1), 23–32. https://doi.org/10.2337/cd24-0003

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IKEM

2024

David, T., Šedinová, M., Myšková, A., Kuneš, J., Maletínská, L., Pohl, R., Dračínský, M., Mertlíková-Kaiserová, H., Čížek, K., Klepetářová, B., Litecká, M., Kaňa, A., Sýkora, D., Jaroš, A., Straka, M., Polášek, M. Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis. Nature Communications. 2024, 15(Nov 13), 9836. https://doi.org/10.1038/s41467-024-53867-1

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Svobodová, G., Šadibolová, M., Velecká, E., Mráziková, L., Vaculová, P., Matoušková, P., Kuneš, J., Maletínská, L., Boušová, I. Metabolic Dysfunction-Associated Steatotic Liver Disease Is Accompanied by Increased Activities of Superoxide Dismutase, Catalase, and Carbonyl Reductase 1 and Levels of miR-200b-3p in Mouse Models. Antioxidants. 2024, 13(11), 1371. https://doi.org/10.3390/antiox13111371

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Morgan, A., Shekhar, N., Strnadová, V., Pirník, Z., Haasová, E., Kopecký, J., Pačesová, A., Železná, B., Kuneš, J., Bardová, K., Maletínská, L. Deficiency of GPR10 and NPFFR2 receptors leads to sex-specific prediabetic syndrome and late-onset obesity in mice. Bioscience Reports. 2024, 44(10), BSR20241103. https://doi.org/10.1042/BSR20241103

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Elblová, P., Lunova, M., Henry, S.J.W., Tu, X.Y., Calé, A., Dejneka, A., Havelková, J., Petrenko, Y., Jirsa, M., Stephanopoulos, N., Lunov, O. Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells. Chemical Engineering Journal. 2024, 498(Oct), 155633. https://doi.org/10.1016/j.cej.2024.155633

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Charvát, V., Strnadová, A., Myšková, A., Sýkora, D., Blechová, M., Železná, B., Kuneš, J., Maletínská, L., Pačesová, A. Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity. European Journal of Pharmacology. 2024, 980(5 October), 176864. https://doi.org/10.1016/j.ejphar.2024.176864

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Mrázková, L., Lubos, M., Voldřich, J., Kužmová, E., Zrubecká, D., Gwozdiaková, P., Buděšínský, M., Asai, S., Marek, A., Pícha, J., Tencerová, M., Ferenčáková, M., Barrera Alquicer, G., Kaminský, J., Jiráček, J., Žáková, L. The final walk with preptin. PLoS ONE. 2024, 19(9), e0309726. https://doi.org/10.1371/journal.pone.0309726

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Gawrys, O., Jíchová, Š., Miklovič, M., Husková, Z., Kikerlová, S., Sadowski, J., Kollárová, P., Lenčová-Popelová, O., Hošková, L., Imig, J. D., Mazurová, Y., Kolář, F., Melenovský, V., Štěrba, M., Červenka, L. Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats. Hypertension Research. 2024, 47(11), 3126–3146. https://doi.org/10.1038/s41440-024-01865-7

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IKEM

Bačáková, L., Chlupáč, J., Filová, E., Musílková, J., Tomšů, J., Wu, Y., Svobodová, L., Pražák, Š., Brož, A. Vascular Damage and Repair, Are Small-Diameter Vascular Grafts Still the “Holy Grail” of Tissue Engineering? Physiological Research. 2024, 73(Suppl.1), S335–S363. https://doi.org/10.33549/physiolres.935294

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IKEM

Rauchová, H., Neprašová, B., Maletínská, L., Kuneš, J. Glutathione Levels and Lipid Oxidative Damage in Selected Organs of Obese Koletsky and Lean Spontaneously Hypertensive Rats. Physiological Research. 2024, 73(3), 481–484. https://doi.org/10.33549/physiolres.935319

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Kasperová, B. J., Mráz, M., Svoboda, P., Hlaváček, D., Kratochvílová, H., Modos, I., Vrzáčková, N., Ivák, P., Janovská, P., Kobets, T., Mahrík, J., Riečan, M., Steiner Mrázová, L., Stránecký, V., Netuka, I., Čajka, T., Kuda, O., Melenovský, V., Štemberková-Hubáčková, S., Haluzík, M. Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure. Cardiovascular Diabetology. 2024, 23(1), 223. https://doi.org/10.1186/s12933-024-02298-9

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IKEM

Jadhav, S. B., Vondráčková, M., Potomova, P., Sandoval-Acuna, C., Šmigová, J., Klanicova, K., Rosel, D., Brabek, J., Štursa, J., Werner, L., Truksa, J. NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation. Frontiers in Pharmacology. 2024, 15(JUN 25 2024), 1422369. https://doi.org/10.3389/fphar.2024.1422369

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IKEM

Marhefková, N., Sládek, M., Sumová, A., Dubský, M. Circadian dysfunction and cardio-metabolic disorders in humans. Frontiers in Endocrinology. 2024, 15(29 April), 1328139. https://doi.org/10.3389/fendo.2024.1328139

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Němečková, I., Eissazadeh, S., Rathouská Urbánková, J., Šilhavý, J., Malínská, H., Pravenec, M., Nachtigal, P. Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats. BMC Cardiovascular Disorders. 2024, 24(1), 211. https://doi.org/10.1186/s12872-024-03870-7

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Hojná, S., Malínská, H., Hüttl, M., Vaňourková, Z., Marková, I., Miklánková, D., Hrdlička, J., Papoušek, F., Neckář, J., Kujal, P., Behuliak, M., Rauchová, H., Kadlecová, M., Sedmera, D., Neffeová, K., Zábrodská, E., Olejníčková, V., Zicha, J., Vaněčková, I. Hepatoprotective and cardioprotective effects of empagliflozin in spontaneously hypertensive rats fed a high-fat diet. Biomedicine & Pharmacotherapy. 2024, 174(May), 116520. https://doi.org/10.1016/j.biopha.2024.116520

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IKEM

Strnadová, V., Pačesová, A., Charvát, V., Šmotková, Z., Železná, B., Kuneš, J., Maletínská, L. Anorexigenic neuropeptides as anti-obesity and neuroprotective agents: exploring the neuroprotective effects of anorexigenic neuropeptides. Bioscience Reports. 2024, 44(4), BSR20231385. https://doi.org/10.1042/BSR20231385

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Strnadová, V., Morgan, A., Škrlová, M., Haasová, E., Bardová, K., Myšková, A., Sýkora, D., Kuneš, J., Železná, B., Maletínská, L. Peripheral administration of lipidized NPAF and NPFF analogs does not influence central food intake regulation but induces anxiety-like behavior. Neuropeptides. 2024, 104(April), 102417. https://doi.org/10.1016/j.npep.2024.102417

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Šuca, H., Čoma, M., Tomšů, J., Sabová, J., Zajíček, R., Brož, A., Doubková, M., Novotný, T., Bačáková, L., Jenčová, V., Kuželová Košťáková, E., Lukačín, Š., Rejman, D., Gál, P. Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review. Journal of Surgical Research. 2024, 296(April), 383–403. https://doi.org/10.1016/j.jss.2023.12.043

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Miklovič, M., Gawrys, O., Honetschlägerová, Z., Kala, P., Husková, Z., Kikerlová, S., Vaňourková, Z., Jíchová, Š., Kvasilová, A., Kitamoto, M., Maxová, H., Puertas-Frias, G., Mráček, T., Sedmera, D., Melenovský, V. Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model. Hypertension Research. 2024, 47(Oct), 2718–2730. https://doi.org/10.1038/s41440-024-01580-3

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Cheema, M. M., Kotrbová Macáková, Z., Hrčka Krausová, B., Adla, S. K., Slavíková, B., Chodounská, H., Kratochvíl, M., Vondrášek, J., Sedlák, D., Balaštík, M., Kudová, E. 5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia. Journal of Steroid Biochemistry and Molecular Biology. 2024, 239(May), 106464. https://doi.org/10.1016/j.jsbmb.2024.106464

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Kysilov, B., Kuchtiak, V., Hrčka Krausová, B., Balík, A., Kořínek, M., Fili, K., Dobrovolski, M., Abramová, V., Chodounská, H., Kudová, E., Božíková, P., Černý, J., Smejkalová, T., Vyklický ml., L. Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids. Cellular and Molecular Life Sciences. 2024, 81(1), 36. https://doi.org/10.1007/s00018-023-05062-6

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Šilhavý, J., Mlejnek, P., Šimáková, M., Liška, F., Malínská, H., Marková, I., Hüttl, M., Miklánková, D., Mušálková, D., Stránecký, V., Kmoch, S., Sticová, E., Vrbacký, M., Mráček, T., Pravenec, M. Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat. Physiological Genomics. 2024, B(1), 65–73. https://doi.org/10.1152/physiolgenomics.00084.2023

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2023

Železná, B., Pačesová, A., Strnadová, V., Kuneš, J., Maletínská, L. Peptid uvolňující prolaktin: neuropeptid s nevhodným jménem, ale vhodnými vlastnostmi pro léčbu obezity, diabetu 2. typu i Alzheimerovy nemoci. Chemické listy. 2023, 117(12), 732–738. https://doi.org/10.54779/chl20230732

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Myšková, A., Sýkora, D., Kuneš, J., Maletínská, L. Lipidization as a tool toward peptide therapeutics. Drug Delivery. 2023, 30(1), 2284685. https://doi.org/10.1080/10717544.2023.2284685

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Holá, L., Tureckiová, T., Kuneš, J., Železná, B., Maletínská, L. High-Fat Diet Induces Resistance to Ghrelin and LEAP2 Peptide Analogs in Mice. Physiological Research. 2023, 72(5), 607–619. https://doi.org/10.33549/physiolres.935189

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Mengr, A., Strnadová, V., Strnad, Š., Vrkoslav, V., Pelantová, H., Kuzma, M., Comptdaer, T., Železná, B., Kuneš, J., Galas, M. C., Pačesová, A., Maletínská, L. Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice. Nutrients. 2023, 15(17), 3690. https://doi.org/10.3390/nu15173690

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Potalitsyn, P., Mrázková, L., Selicharová, I., Tencerová, M., Ferenčáková, M., Chrudinová, M., Turnovská, T., Brzozowski, A. M., Marek, A., Kaminský, J., Jiráček, J., Žáková, L. Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2. Communications Biology. 2023, 6, 863. https://doi.org/10.1038/s42003-023-05239-6

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Sivčev, S., Kudová, E., Zemková, H. Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective. Neuropharmacology. 2023, 234(Aug 15), 109542. https://doi.org/10.1016/j.neuropharm.2023.109542

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Piťha, J., Vaněčková, I., Zicha, J. Hypertension after the Menopause: What Can We Learn from Experimental Studies? Physiological Research. 2023, 72(Suppl.2), 91–112. https://doi.org/10.33549/physiolres.935151

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Kuneš, J., Hojná, S., Mráziková, L., Montezano, A., Touyz, R. M., Maletínská, L. Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms. Physiological Research. 2023, 72(Suppl.2), 73–90. https://doi.org/10.33549/physiolres.935109

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Plecitá-Hlavatá, L., Brázdová, A., Křivonosková, M., Hu, Ch.-J., Phang, T., Tauber, J., Li, M., Zhang, H., Hoetzenecker, K., Crnkovic, S., Kwapiszewska, G., Stenmark, K. R. Microenvironmental regulation of T-cells in pulmonary hypertension. Frontiers in Immunology. 2023, 14(Jul 11), 1223122. https://doi.org/10.3389/fimmu.2023.1223122

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Kortus, Š., Řeháková, K., Klíma, M., Kolcheva, M., Ladislav, M., Langore, E., Baráčková, P., Netolický, J., Misiachna, A., Hemelíková, K., Humpolíčková, J., Chalupská, D., Šilhán, J., Kaniaková, M., Hrčka Krausová, B., Bouřa, E., Zápotocký, M., Horák, M. Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes. Journal of Neuroscience. 2023, 43(26), 4755–4774. https://doi.org/10.1523/jneurosci.2014-22.2023

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Freitas-Lima, L. C., Pačesová, A., Staňurová, J., Šácha, P., Marek, A., Hubálek, M., Kuneš, J., Železná, B., Maletínská, L. GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript peptide. European Journal of Pharmacology. 2023, 949(Jun 15), 175713. https://doi.org/10.1016/j.ejphar.2023.175713

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Husková, Z., Kikerlová, S., Miklovič, M., Kala, P., Papoušek, F., Neckář, J. Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension. Frontiers in Physiology. 2023, 14(Jun 14), 1151308. https://doi.org/10.3389/fphys.2023.1151308

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Karnošová, A., Strnadová, V., Železná, B., Kuneš, J., Kašpárek, P., Maletínská, L. NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose. Clinical science. 2023, 137(10), 847–862. https://doi.org/10.1042/cs20220880

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Abramová, V., Alvarado, V. L., Hill, M., Smejkalová, T., Malý, M., Valeš, K., Dittert, I., Božíková, P., Kysilov, B., Hrčka Krausová, B., Vyklický, V., Balík, A., Fili, K., Kořínek, M., Chodounská, H., Kudová, E., Číž, D., Martinovič, J., Bartůněk, P., Vyklický ml., L. Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior. ACS Chemical Neuroscience. 2023, 14(10), 1870–1883. https://doi.org/10.1021/acschemneuro.3c00131

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Rehák Bučková, B., Kala, D., Kořenek, J., Matušková, V., Kumpošt, V., Svobodová, L., Otáhal, J., Škoch, A., Šulc, V., Olšerová, A., Vyhnálek, M., Janský, P., Tomek, A., Marusič, P., Jiruška, P., Hlinka, J. Structural connectivity-based predictors of cognitive impairment in stroke patients attributable to aging. PLoS ONE. 2023, 18(4), e0280892. https://doi.org/10.1371/journal.pone.0280892

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Šilhavý, J., Mlejnek, P., Šimáková, Miroslava, Marková, I., Malínská, H., Hüttl, M., Kazdová, L., Kazantsev, D., Mancini, M., Novotný, J., Pravenec, M. CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study. PLoS ONE. 2023, 18(4), e0283276. https://doi.org/10.1371/journal.pone.0283276

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Pelantová, H., Tomášová, P., Šedivá, B., Neprašová, B., Mráziková, L., Kuneš, J., Železná, B., Maletínská, L., Kuzma, M. Metabolomic Study of Aging in fa/fa Rats: Multiplatform Urine and Serum Analysis. Metabolites. 2023, 13(4), 552. https://doi.org/10.3390/metabo13040552

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Hüttl, M., Marková, I., Miklánková, D., Zapletalová, I., Kujal, P., Šilhavý, J., Pravenec, M., Malínská, H. Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model. Frontiers in Pharmacology. 2023, 14(Apr 3), 1117683. https://doi.org/10.3389/fphar.2023.1117683

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Strnadová, V., Karnošová, A., Blechová, M., Neprašová, B., Holá, L., Němcová, A., Myšková, A., Sýkora, D., Železná, B., Kuneš, J., Maletínská, L. Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies. Neuropeptides. 2023, 98(April), 102319. https://doi.org/10.1016/j.npep.2022.102319

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Habart, D., Koza, A., Leontovyč, I., Kosinová, L., Berková, Z., Kříž, J., Zacharovová, K., Brinkhof, B., Cornelissen, D. J., Magrane, N., Bittenglová, K., Čapek, M., Valečka, J., Habartová, A., Saudek, F. IsletSwipe, a mobile platform for expert opinion exchange on islet graft images. Islets. 2023, 15(1), 2189873. https://doi.org/10.1080/19382014.2023.2189873

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Kynčl, M., Holubová, Z., Tintěra, J., Profantová, N., Šanda, J., Kala, D., Prysiazhniuk, Y., Kudr, M., Kršek, P., Kalina, A., Zárubová, J., Komárek, V., Otáhal, J., Marusič, P. Doporučení pro strukturální zobrazení MR mozku v diagnostice epilepsie. Česká a Slovenská neurologie a neurochirurgie. 2023, 86(1), 18–24

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Kala, P., Vaňourková, Z., Škaroupková, P., Kompanowska, J., E., Sadowski, J., Walkowska, A., Veselka, J., Táborský, M., Maxová, H., Vaněčková, I., Červenka, L. Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula. Biomedicine & Pharmacotherapy. 2023, 158(Feb), 114157. https://doi.org/10.1016/j.biopha.2022.114157

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Šilhavý, J., Mlejnek, P., Šimáková, M., Malínská, H., Marková, I., Hüttl, M., Miklánková, D., Kazdová, L., Vrbacký, M., Pecinová, A., Mráček, T., Pravenec, M. Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome. Metabolites. 2023, 13(2), 192. https://doi.org/10.3390/metabo13020192

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Mráziková, L., Hojná, S., Vaculová, P., Strnad, Š., Vrkoslav, V., Pelantová, H., Kuzma, M., Železná, B., Kuneš, J., Maletínská, L. Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance. Nutrients. 2023, 15(2), 280. https://doi.org/10.3390/nu15020280

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Szczurowska, E., Szánti-Pintér, E., Chetverikov, N., Randáková, A., Kudová, E., Jakubík, J. Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids. International Journal of Molecular Sciences. 2023, 24(1), 507. https://doi.org/10.3390/ijms24010507

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Kolcheva, M., Ladislav, M., Netolický, J., Kortus, Š., Řeháková, K., Hrčka Krausová, B., Hemelíková, K., Misiachna, A., Kádková, A., Klíma, M., Chalupská, D., Horák, M. The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors. Neuropharmacology. 2023, 222(Jan 1), 109297. https://doi.org/10.1016/j.neuropharm.2022.109297

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Kala, P., Gawrys, O., Miklovic, M., Vaňourková, Z., Škaroupková, P., Jíchová, Š., Sadowski, J., Kompanowska, J., E., Walkowska, A., Veselka, J., Táborský, M., Maxová, H., Vaněčková, I., Červenka, L. Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension. Journal of Hypertension. 2023, 41(1), 99–114. https://doi.org/10.1097/hjh.0000000000003307

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2022

Holá, L., Železná, B., Karnošová, A., Kuneš, J., Fehrentz, J. A., Denoyelle, S., Cantel, S., Blechová, M., Sýkora, D., Myšková, A., Maletínská, L. A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin. Journal of Pharmacology and Experimental Therapeutics. 2022, 383(2), 129–136. https://doi.org/10.1124/jpet.122.001322

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Szczurowska, E., Szánti-Pintér, E., Randáková, A., Jakubík, J., Kudová, E. Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids. International Journal of Molecular Sciences. 2022, 23(21), 13075. https://doi.org/10.3390/ijms232113075

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Hojná, S., Kotsaridou, Z., Vaňourková, Z., Rauchová, H., Behuliak, M., Kujal, P., Kadlecová, M., Zicha, J., Vaněčková, I. Empagliflozin Is Not Renoprotective in Non-Diabetic Rat Models of Chronic Kidney Disease. Biomedicines. 2022, 10(10), 2509. https://doi.org/10.3390/biomedicines10102509

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Pačesová, A., Holubová, M., Hrubá, L., Strnadová, V., Neprašová, B., Pelantová, H., Kuzma, M., Železná, B., Kuneš, J., Maletínská, L. Age-related metabolic and neurodegenerative changes in SAMP8 mice. Aging. 2022, 14(18), 7300–7327. https://doi.org/10.18632/aging.204284

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Malínská, H., Hüttl, M., Marková, I., Miklánková, D., Hojná, S., Papoušek, F., Šilhavý, J., Mlejnek, P., Zicha, J., Hrdlička, J., Pravenec, M., Vaněčková, I. Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein. Biomedicines. 2022, 10(9), 2066. https://doi.org/10.3390/biomedicines10092066

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Mráziková, L., Hojná, S., Pačesová, A., Hrubá, L., Strnadová, V., Neprašová, B., Železná, B., Kuneš, J., Maletínská, L. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances. Nutrition & Diabetes. 2022, 12(1), 26. https://doi.org/10.1038/s41387-022-00205-3

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Oeckl, J., Janovská, P., Adamcová, K., Bardová, K., Brunner, S., Dieckmann, S., Ecker, J., Fromme, T., Funda, J., Gantert, T., Giansanti, P., Soledad Hidrobo, M., Kuda, O., Kuster, B., Li, Y., Pohl, R., Schmitt, S., Schweizer, S., Zischka, H., Zouhar, P., Kopecký, J., Klingenspor, M. Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Molecular Metabolism. 2022, 61(July), 101499. https://doi.org/10.1016/j.molmet.2022.101499

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Shapoval, O., Engstová, H., Jirák, D., Drahokoupil, J., Sulková, K., Berková, Z., Pop-Georgievski, O., Holendová, B., Ježek, P., Horák, D. Poly(4-Styrenesulfonic Acid-co-maleic Anhydride)-Coated NaGdF₄:Yb,Tb,Nd Nanoparticles with Luminescence and Magnetic Properties for Imaging of Pancreatic Islets and β-Cells. ACS Applied Materials and Interfaces. 2022, 14(16), 18233–18247. https://doi.org/10.1021/acsami.2c04274

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Mandal, R., Kohoutová, K., Petrvalská, O., Horváth, M., Srb, P., Veverka, V., Obšilová, V., Obšil, T. FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA. Protein Science. 2022, 31(5), e4287. https://doi.org/10.1002/pro.4287

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Kysilov, B., Hrčka Krausová, B., Vyklický, V., Smejkalová, T., Kořínek, M., Horák, M., Chodounská, H., Kudová, E., Černý, J., Vyklický ml., L. Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations. British Journal of Pharmacology. 2022, 179(15), 3970–3990. https://doi.org/10.1111/bph.15841

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Senko, A. N., Overall, R. W., Šilhavý, J., Mlejnek, P., Malínská, H., Hüttl, M., Marková, I., Fabel, K. S., Lu, L., Stuchlík, A., Williams, R. W., Pravenec, M., Kempermann, G. Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose. PLoS Genetics. 2022, 18(4), e1009638. https://doi.org/10.1371/journal.pgen.1009638

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Chlupáč, J., Matějka, R., Koňařík, M., Novotný, R., Šimůnková, Z., Mrázová, I., Fabian, O., Zapletal, M., Pulda, Z., Lipenský, J. F., Štěpanovská, J., Hanzálek, K., Brož, A., Novák, T., Lodererová, A., Voska, L., Adla, T., Froněk, J., Rozkot, M., Forostyak, S., Kneppo, P., Bačáková, L., Pirk, J. Vascular Remodeling of Clinically Used Patches and Decellularized Pericardial Matrices Recellularized with Autologous or Allogeneic Cells in a Porcine Carotid Artery Model. International Journal of Molecular Sciences. 2022, 23(6), 3310. https://doi.org/10.3390/ijms23063310

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Magalhaes-Novais, S., Blecha, J., Naraine, R., Mikesova, J., Abaffy, P., Pecinová, A., Miloševič, M., Bohuslavová, R., Procházka, J., Khan, S., Novotná, E., Šindelka, R., Machan, R., Dewerchin, M., Vlčák, E., Kalucka, J., Štemberková-Hubáčková, S., Benda, A., Goveia, J., Mráček, T., Bařinka, C., Carmeliet, P., Neužil, J., Rohlenová, K., Rohlena, J. Mitochondrial respiration supports autophagy to provide stress resistance during quiescence. Autophagy. 2022, 2022–03-21(MAR 2022). https://doi.org/10.1080/15548627.2022.2038898

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Šilhavý, J., Mlejnek, P., Šimáková, M., Liška, F., Kubovčiak, J., Sticová, E., Pravenec, M. Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension. Biomedicines. 2022, 10(2), 376. https://doi.org/10.3390%2Fbiomedicines10020376

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Kudová, E., Mareš, P., Hill, M., Vondráková, K., Tsenov, G., Chodounská, H., Kubová, H., Valeš, K. The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains. Pharmaceuticals. 2022, 15(1), 49. https://doi.org/10.3390/ph15010049

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Imig, J. D., Červenka, L., Neckář, J. Epoxylipids and soluble epoxide hydrolase in heart diseases. Biochemical Pharmacology. 2022, 195(Jan), 114866. https://doi.org/10.1016/j.bcp.2021.114866

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2021

Pravenec, M., Šilhavý, J., Mlejnek, P., Šimáková, M., Mráček, T., Pecinová, A., Tauchmannová, K., Hüttl, M., Malínská, H., Kazdová, L., Neckář, J., Kolář, F., Žurmanová, J., Novotný, J., Houštěk, J. Conplastic Strains for Identification of Retrograde Effects of Mitochondrial DNA Variation on Cardiometabolic Traits in the Spontaneously Hypertensive Rat. Physiological Research. 2021, 70(Suppl.4), S471–S481. https://doi.org/10.33549%2Fphysiolres.934740

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Mráziková, L., Neprašová, B., Mengr, A., Popelová, A., Strnadová, V., Holá, L., Železná, B., Kuneš, J., Maletínská, L. Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models. Frontiers in Pharmacology. 2021, 12(Nov 18), 779962. https://doi.org/10.3389/fphar.2021.779962

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Hüttl, M., Marková, I., Miklánková, D., Zapletalová, I., Poruba, M., Haluzík, M., Vaněčková, I., Malínská, H. In a Prediabetic Model, Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia. International Journal of Molecular Sciences. 2021, 22(21), 11513. https://doi.org/10.3390%2Fijms222111513

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Hojná, S., Rauchová, H., Malínská, H., Marková, I., Hüttl, M., Papoušek, F., Behuliak, M., Miklánková, D., Vaňourková, Z., Neckář, J., Kadlecová, M., Kujal, P., Zicha, J., Vaněčková, I. Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats, an experimental non-diabetic model of hypertension. Biomedicine & Pharmacotherapy. 2021, 144(Dec), 112246. https://doi.org/10.1016/j.biopha.2021.112246

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Dolejší, E., Szánti-Pintér, E., Chetverikov, N., Nelic, D., Randáková, A., Doležal, V., Kudová, E., Jakubík, J. Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptors. Neuropharmacology. 2021, 199(Nov 1), 108798. https://doi.org/10.1016/j.neuropharm.2021.108798

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Mengr, A., Hrubá, L., Exnerová, A., Holubová, M., Popelová, A., Železná, B., Kuneš, J., Maletínská, L. Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study. Current Alzheimer Research. 2021, 18(8), 607–622. http://dx.doi.org/10.2174/1567205018666210922110652

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Krijt, J., Sokolová, J., Šilhavý, J., Mlejnek, P., Kubovčiak, J., Liška, F., Malínská, H., Hüttl, M., Marková, I., Křížková, M., Stipanuk, M. H., Křížek, T., Ditroi, T., Nagy, P., Kožich, V., Pravenec, M. High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats. Physiological Research. 2021, 70(5), 687–700. https://doi.org/10.33549%2Fphysiolres.934736

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Neckář, J., Alánová, P., Olejníčková, V., Papoušek, F., Hejnová, L., Šilhavý, J., Behuliak, M., Bencze, M., Hrdlička, J., Vecka, M., Jarkovská, D., Švíglerová, J., Mistrová, E., Štengl, M., Novotný, J., Ošťádal, B., Pravenec, M., Kolář, F. Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats. Clinical science. 2021, 135(17), 2143–2163. https://doi.org/10.1042/cs20210648

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Pirník, Z., Kořínková, L., Osacká, J., Železná, B., Kuneš, J., Maletínská, L.. Cholecystokinin System Is Involved in the Anorexigenic Effect of Peripherally Applied Palmitoylated Prolactin-Releasing Peptide in Fasted Mice. Physiological Research. 2021, 70(4), 579–590. https://doi.org/10.33549/physiolres.934694

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Karnošová, A., Strnadová, V., Holá, L., Železná, B., Kuneš, J., Maletínská, L.. Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10, NPFF-R2 and NPFF-R1 Receptors: In Vitro Study. International Journal of Molecular Sciences. 2021, 22(16), 8904. https://doi.org/10.3390/ijms22168904

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Dolejší, E., Chetverikov, N., Szánti-Pintér, E., Nelic, D., Randáková, A., Doležal, V., El-Fakahany, E. E., Kudová, E., Jakubík, J. Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors. Biochemical Pharmacology. 2021, 192(Oct), 114699. https://doi.org/10.1016/j.bcp.2021.114699

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Holubová, K., Chvojková, M., Hrčka Krausová, B., Vyklický, V., Kudová, E., Chodounská, H., Vyklický ml., L., Valeš, K. Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia. Biomolecules. 2021, 11(7), 1026. https://doi.org/10.3390%2Fbiom11071026

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Kacířová, M., Železná, B., Blažková, M., Holubová, M., Popelová, A., Kuneš, J., Šedivá, B., Maletínská, L.. Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22. Journal of Neuroinflammation. 2021, 18(1), 141. https://doi.org/10.1186/s12974-021-02190-3

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Boušová, K., Bednárová, L., Zouharová, M., Vetýšková, V., Poštulková, K., Hofbauerová, K., Petrvalská, O., Vaněk, O., Tripsianes, K., Vondrášek, J. The order of PDZ3 and TrpCage in fusion chimeras determines their properties—a biophysical characterization. Protein Science. 2021, 30(8), 1653–1666. https://doi.org/10.1002/pro.4107

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Husková, Z., Kikerlová, S., Sadowski, J., Alánová, P., Sedláková, L., Papoušek, F., Neckář, J. Increased Endogenous Activity of the Renin-Angiotensin System Reduces Infarct Size in the Rats with Early Angiotensin II-dependent Hypertension which Survive the Acute Ischemia/Reperfusion Injury. Frontiers in Pharmacology. 2021, 12(May 28), 679060. https://doi.org/10.3389/fphar.2021.679060

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Smejkalová, T., Kořínek, M., Krůšek, J., Hrčka Krausová, B., Candelas Serra, M., Hajduković, D., Kudová, E., Chodounská, H., Vyklický ml., L. Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms. British Journal of Pharmacology. 2021, 178(19), 3888–3904. https://doi.org/10.1111/bph.15529

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Junková, K., Mirchi, L. F., Chylíková, B., Janků, M., Šilhavý, J., Hüttl, M., Marková, I., Miklánková, D., Včelák, J., Malínská, H., Pravenec, M., Šeda, O., Liška, F. Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation. Nutrients. 2021, 13(5), 1462. https://doi.org/10.3390/nu13051462

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Uchytilová, E., Špicarová, D., Paleček, J. Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist. International Journal of Molecular Sciences. 2021, 22(7), 3712. https://doi.org/10.3390%2Fijms22073712

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Pražienková, V., Funda, J., Pirník, Z., Karnošová, A., Hrubá, L., Kořínková, L., Neprašová, B., Janovská, P., Bencze, M., Kadlecová, M., Blahoš, J., Kopecký, J., Železná, B., Kuneš, J., Bardová, K., Maletínská, L. GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis. Gene. 2021, 774(Mar 30), 145427. https://doi.org/10.1016/j.gene.2021.145427

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Hubálková, P., Ladislav, M., Vyklický, V., Smejkalová, T., Hrčka Krausová, B., Kysilov, B., Krůšek, J., Naimová, Ž., Kořínek, M., Chodounská, H., Kudová, E., Černý, J., Vyklický ml., L. Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity. Journal of Neuroscience. 2021, 41(10), 2119–2134. https://doi.org/10.1523/jneurosci.2654-20.2021

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Krausová, A., Burešová, P., Sarnová, L., Oyman-Eyrilmez, G., Škarda, J., Wohl, P., Bajer, L., Sticová, E., Bartoňová, L., Pácha, J., Koubková, G., Procházka, J., Sporrer, M., Durrbeck, C., Stehlíková, Zuzana, V., M., Ziolkowska, N., Sedláček, R., Jirák, D., Kverka, M., Wiche, G., Fabry, B., Kořínek, V., Gregor, M. Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal Immunology. 2021, 14(3), 691–702. https://doi.org/10.1038/s41385-021-00380-z

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Filová, E., Steinerová, M., Trávníčková, M., Knitlová, J., Musílková, J., Eckhardt, A., Hadraba, D., Matějka, R., Pražák, Š., Štěpanovská, J., Kučerová, J., Riedel, T., Brynda, E., Lodererová, A., Honsová, E., Pirk, J., Koňařík, M., Bačáková, L. Accelerated in vitro recellularization of decellularized porcine pericardium for cardiovascular grafts. Biomedical Materials. 2021, 16(2), 025024. https://doi.org/10.1088/1748-605X/abbdbd

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Honetschlagerová, Z., Gawrys, O., Jíchová, Š., Škaroupková, P., Kikerlová, S., Vaňourková, Z., Husková, Z., Melenovský, V., Kompanowska., Jezierska, E., Sadowski, J., Kolář, F., Novotný, J., Hejnová, L., Kujal, P., Červenka, L. Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula. Kidney & Blood Pressure Research. 2021, 46(1), 95–113. https://doi.org/10.1159/000513071

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Ošťádal, B., Ošťádalová, I., Szárszoi, O., Netuka, I., Olejníčková, V., Hlaváčková, M. Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults. Canadian Journal of Physiology and Pharmacology. 2021, 99(1), 1–8. https://doi.org/10.1139/cjpp-2020-0310

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Brejchová, K., Radner, F. P. W., Balas, L., Palůchová, V., Čajka, T., Chodounská, H., Kudová, E., Schratter, M., Schreiber, R., Durand, T., Zechner, R., Kuda, O. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(2), e2020999118. https://doi.org/10.1073/pnas.2020999118

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2020

Bardová, K., Funda, J., Pohl, R., Čajka, T., Hensler, M., Kuda, O., Janovská, P., Adamcová, K., Irodenko, I., Leňková, L., Zouhar, P., Horáková, O., Flachs, P., Rossmeisl, M., Colca, J., Kopecký, J. Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/Fatty Acid Cycling in Adipose Tissue. Nutrients. 2020, 12(12), 3737. https://doi.org/10.3390/nu12123737

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Šilhavý, J., Malínská, H., Hüttl, M., Marková, I., Oliyarnyk, O., Mlejnek, P., Šimáková, M., Liška, F., Kazdová, L., Moravcová, R., Novotný, J., Pravenec, M. Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats. ANTIOXIDANTS. 2020, 9(12), 1179. https://doi.org/10.3390%2Fantiox9121179

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Kořínková, L., Pražienková, V., Černá, L., Karnošová, A., Železná, B., Kuneš, J., Maletínská, L. Pathophysiology of NAFLD and NASH in Experimental Models: The Role of Food Intake Regulating Peptides. Frontiers in Endocrinology. 2020, 11(Nov 26), 597583. https://doi.org/10.3389%2Ffendo.2020.597583

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Pavlišová, J., Horáková, O., Kalendová, V., Burešová, J., Bardová, K., Holendová, B., Plecitá-Hlavatá, L., Vacková, Š., Windrichová, J., Topolčan, O., Kopecký, J., Rossmeisl, M. Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice. Food & Function. 2020, 11(11), 9764–9775. https://doi.org/10.1039/D0FO01942A

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Janovská, P., Melenovský, V., Svobodová, M., Havlenová, T., Kratochvílová, H., Haluzík, M., Hošková, E., Pelikánová, T., Kautzner, J., Monzo, L., Jurcová, I., Adamcová, K., Leňková, L., Burešová, J., Rossmeisl, M., Kuda, O., Čajka, T., Kopecký, J. Dysregulation of epicardial adipose tissue in cachexia due to heart failure: the role of natriuretic peptides and cardiolipin. Journal of Cachexia Sarcopenia and Muscle. 2020, 11(6), 1614–1627. https://doi.org/10.1002/jcsm.12631

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Kosek, V., Heczková, M., Novák, F., Meisnerová, E., Nováková, O., Zelenka, J., Bechyňská, K., Vrzáčová, N., Suttnar, J., Hlaváčková, A., Danková, H., Bratová, M., Dasková, N., Malínská, H., Oliyarnyk, O., Wohl, P., Bastová, H., Hajslová, J., Cahová, M. The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach. Nutrients. 2020, 12(8), 2351. https://doi.org/10.3390/nu12082351

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Zmeškalová, A., Popelová, A., Exnerová, A., Železná, B., Kuneš, J., Maletínská, L. Cellular Signaling and Anti-Apoptotic Effects of Prolactin-Releasing Peptide and Its Analog on SH-SY5Y Cells. International Journal of Molecular Sciences. 2020, 21(17), 6343. https://doi.org/10.3390%2Fijms21176343

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Matějka, R., Koňařík, M., Štěpanovská, J., Lipenský, J., Chlupáč, J., Turek, D., Pražák, Š., Brož, A., Šimůnková, Z., Mrázová, I., Forostyak, S., Kneppo, P., Rosina, J., Bačáková, L., Pirk, J. Bioreactor Processed Stromal Cell Seeding and Cultivation on Decellularized Pericardium Patches for Cardiovascular Use. Applied Sciences-Basel. 2020, 10(16), 5473. https://doi.org/10.3390/app10165473

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Hrčka Krausová, B., Kysilov, B., Černý, J., Vyklický, V., Smejkalová, T., Ladislav, M., Balík, A., Kořínek, M., Chodounská, H., Kudová, E., Vyklický ml., L. Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor. Journal of Neuroscience. 2020, 40(31), 5922–5936. https://doi.org/10.1523%2FJNEUROSCI.3010-19.2020

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Sivčev, S., Slavíková, B., Ivetic, M., Knězů, M., Kudová, E., Zemková, H. Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel gating. Journal of Steroid Biochemistry and Molecular Biology. 2020, 202(Sep), 105725. https://doi.org/10.1016/j.jsbmb.2020.105725

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Mareš, P., Kudová, E., Valeš, K., Kubová, H. Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats. Pharmacological Reports. 2020, 72(6), 1573–1578. https://doi.org/10.1007/s43440-020-00113-2

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Smolková, K., Špačková, J., Gotvaldová, K., Dvořák, A., Křenková, A., Hubálek, M., Holendová, B., Vítek, L., Ježek, P. SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2. Scientific Reports. 2020, 10(1), 8677. https://doi.org/10.1038/s41598-020-65351-z

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Chvojková, M., Rambousek, L., Chodounská, H., Kudová, E., Valeš, K. Synthetic structural modifications of neurosteroid pregnanolone sulfate: Assessment of neuroprotective effects in vivo. European Journal of Pharmacology. 2020, 881(Aug 15), 173187. https://doi.org/10.1016/j.ejphar.2020.173187

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Strnad, Š., Pražienková, V., Holubová, M., Sýkora, D., Cvačka, J., Maletínská, L., Železná, B., Kuneš, J., Vrkoslav, V. Mass spectrometry imaging of free-floating brain sections detects pathological lipid distribution in a mouse model of Alzheimer's-like pathology. Analyst. 2020, 145(13), 4595–4605. https://doi.org/10.1039/D0AN00592D

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IOCB

Plecitá-Hlavatá, L., Jabůrek, M., Holendová, B., Tauber, J., Pavluch, V., Berková, Z., Cahová, M., Schröder, K., Brandes, R. P., Siemen, D., Ježek, P. Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4. Diabetes. 2020, 69(7), 1341–1354. https://doi.org/10.2337/db19-1130

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IKEM

Kubánek, M., Schimerová, T., Piherová, L., Brodehl, A., Krebsová, A., Ratnavadivel, S., Stanasiuk, C., Hansíková, H., Zeman, J., Paleček, T., Houštěk, J., Drahota, Z., Nůsková, H., Mikešová, J., Zámečník, J., Macek, M. Jr., Ridzoň, P., Malusková, J., Stránecký, V., Melenovský, V., Milting, H., Kmoch, S. Desminopathy: Novel desmin variants, a new cardiac phenotype, and further evidence for secondary mitochondrial dysfunction. Journal of Clinical Medicine. 2020, 9(4):E937. https://doi.org/10.3390/jcm9040937

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IKEM

Filová, E., Staňková, Ľ., Eckhardt, A., Svobodová, J., Musílková, J., Pala, J., Hadraba, D., Brynda, E., Koňařík, M., Pirk, J., Bačáková, L. Modification of Human Pericardium by Chemical Crosslinking. Physiological Research. 2020, 69(1), 49–59. https://doi.org/10.33549%2Fphysiolres.934335

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Kacířová, M., Zmeškalová, A., Kořínková, L., Železná, B., Kuneš, J., Maletínská, L. Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer's disease-like pathology? Clinical science. 2020, 134(5), 547–570. https://doi.org/10.1042/cs20191313

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Kořínková, L., Holubová, M., Neprašová, B., Hrubá, L., Pražienková, V., Bencze, M., Haluzík, M., Kuneš, J., Maletínská, L., Železná, B. Synergistic effect of leptin and lipidized PrRP on metabolic pathways in ob/ob mice. Journal of Molecular Endocrinology. 2020, 64(2), 77–90. https://doi.org/10.1530/jme-19-0188

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IOCB

Palůchová, V., Oseeva, M., Březinová, M., Čajka, T., Bardová, K., Adamcová, K., Žáček, P., Brejchová, K., Balas, L., Chodounská, H., Kudová, E., Schreiber, R., Zechner, R., Durand, T., Rossmeisl, M., Abumrad, N. A., Kopecký, J., Kuda, O. Lipokine 5-PAHSA is regulated by adipose triglyceride lipase and primes adipocytes for de novo lipogenesis in mice. Diabetes. 2020, 69(3), 300–312. https://doi.org/10.2337/db19-0494

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Sládek, M., Röschová, M., Adámková, V., Hamplová, D., Sumová, A. Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe. Scientific Reports. 2020, 10(1), 1419. https://doi.org/10.1038/s41598-020-58413-9

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2019

Musílková, J., Filová, E., Pala, J., Matějka, R., Hadraba, D., Vondrášek, D., Kaplan, O., Riedel, T., Brynda, E., Kučerová, J., Koňařík, M., Lopot, F., Pirk, J., Bačáková, L. Human decellularized and crosslinked pericardium coated with bioactive molecular assemblies. Biomedical Materials. 2019, 15(1), 015008. https://doi.org/10.1088/1748-605X/ab52db

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Pšenáková, K., Hexnerová, R., Srb, P., Obšilová, V., Veverka, V., Obšil, T. The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress. FEBS Journal. 2019, 287(8), 1626), 1644. https://doi.org/10.1111/febs.15101

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IOCB

Tomášová, P., Bugáňová, M., Pelantová, H., Holubová, M., Šedivá, B., Železná, B., Haluzík, M., Maletínská, L., Kuneš, J., Kuzma, M. Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination. Applied Biochemistry and Biotechnology. 2019, 188(1), 165–184. https://doi.org/10.1007/s12010-018-2899-8

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IOCB

Holubová, M., Hrubá, L., Popelová, A., Bencze, M., Pražienková, V., Gengler, S., Kratochvílová, H., Haluzík, M., Železná, B., Kuneš, J., Hölscher, C., Maletínská, L. Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology. Neuropharmacology. 2019, 144(Jan), 377–387. https://doi.org/10.1016/j.neuropharm.2018.11.002

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IOCB

Čermáková, M., Pelantová, H., Neprašová, B., Šedivá, B., Maletínská, L., Kuneš, J., Tomášová, P., Železná, B., Kuzma, M. Metabolomic Study of Obesity and Its Treatment with Palmitoylated Prolactin-Releasing Peptide Analog in Spontaneously Hypertensive and Normotensive Rats. Journal of Proteome Research. 2019, 18(4), 1735–1750. https://doi.org/10.1021/acs.jproteome.8b00964

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IOCB

Maletínská, L., Popelová, A., Železná, B., Bencze, M., Kuneš, J. The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology. Journal of Endocrinology. 2019, 240(2), R47–R72. https://doi.org/10.1530/joe-18-0532

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IOCB

Pražienková, V., Schirmer, C., Holubová, M., Železná, B., Kuneš, J., Galas, M. C., Maletínská, L. Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons. Journal of Alzheimer's Disease. 2019, 67(4), 1187–1200. https://doi.org/10.3233/jad-180837

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IOCB

Pražienková, V., Popelová, A., Kuneš, J., Maletínská, L. Prolactin-Releasing Peptide: Physiological and Pharmacological Properties. International Journal of Molecular Sciences. 2019, 20(21), 5297. https://doi.org/10.3390/ijms20215297

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IOCB

Pšenáková, K., Kohoutová, K., Obšilová, V., Ausserlechner, M. J., Veverka, V., Obšil, T. Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics. Cells. 2019, 8(9), 966. https://doi.org/10.3390/cells8090966

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IOCB

Sivčev, S., Slavíková, B., Rupert, M., Ivetic, M., Nekardová, M., Kudová, E., Zemková, H. Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating. Journal of Neurochemistry. 2019, 150(1), 28–43. https://doi.org/10.1111/jnc.14718

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IOCB

Šmídová, A., Staňková, K., Petrvalská, O., Lazar, J., Sychrová, H., Obšil, T., Zimmermannová, O., Obšilová, V. The activity of Saccharomyces cerevisiae Na+, K+/H+ antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481. Biochimica Et Biophysica Acta-Molecular Cell Research. 2019, 1866(12), 118534. https://doi.org/10.1016/j.bbamcr.2019.118534

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Šoltésová, M., Elicharová, H., Srb, P., Růžička, M., Janisova, L., Sychrová, H., Lang, J. Nuclear magnetic resonance investigation of water transport through the plasma membrane of various yeast species. FEMS Microbiology Letters. 2019, 366(18), fnz220. https://doi.org/10.1093/femsle/fnz220

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IOCB

Beyrand, V., Voeten, D. F. A. E., Bureš, S., Fernandez, V., Janáček, J., Jirák, D., Rauhut, O., Tafforeau, P. Multiphase progenetic development shaped the brain of flying archosaurs. Scientific Reports. 2019, 9(Jul 25), 10807. https://doi.org/10.1038/s41598-019-46959-2

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IKEM

Čertíková Chábová, V., Kujal, P., Vaňourková, Z., Škaroupková, P., Sadowski, J., Kompanowska-Jezierska, E., Tesař, V., Hammock, B., Imig, J., Maxová, H., Červenka, L., Vaněčková, I. Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats. Kidney & Blood Pressure Research. 2019, 44(6), 1493–1505. https://doi.org/10.1159/000504137

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IKEM

Hrdlička, J., Neckář, J., Papoušek, F., Husková, Z., Kikerlová, S., Vaňourková, Z., Vernerová, Z., Akat, F., Vašinová, J., Hammock, B.D., Hwang, S.H., Imig, J. D., Falck, J. R., Červenka, L., Kolář, F. Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats. Frontiers in Pharmacology. 2019, 10(Mar 1), 159. https://doi.org/10.3389/fphar.2019.00159

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IKEM

Janáček, J., Jirák, D. Volume tensor estimation using a virtual line grid: study of a developing pheasant brain. Image Analysis and Stereology. 2019, 38(3), 255–260. https://doi.org/10.5566/ias.1701

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Janáček, J., Jirák, D. Variance of the isotropic uniform systematic sampling. Image Analysis and Stereology. 2019, 38(3), 261–267. https://doi.org/10.5566/ias.2218

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IKEM

Krátký, V., Kikerlová, S., Husková, Z., Sadowski, J., Kolář, F., Červenka, L. Enhanced Renal Vascular Responsiveness to Angiotensin II and Norepinephrine: A Unique Feature of Female Rats with Congestive Heart Failure. Kidney & Blood Pressure Research. 2019, 44(5), 1128–1141. https://doi.org/10.1159/000502379

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IKEM

Neckář, J., Khan, M. A. H., Gross, G. J., Cyprová, M., Hrdlička, J., Kvasilová, A., Falck, J. R., Campbell, W. B., Sedláková, L., Škutová, Š., Olejníčková, V., Gregorovičová, M., Sedmera, D., Kolář, F., Imig, J. D. Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. Clinical science. 2019, 133(8), 939–951. https://doi.org/10.1042/cs20180728

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Řezáčová, L., Hojná, S., Kopkan, L., Rauchová, H., Kadlecová, M., Zicha, J., Vaněčková, I. Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation. Biomedicine & Pharmacotherapy. 2019, 116(Aug), 108996. https://doi.org/10.1016/j.biopha.2019.108996

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Svoboda, P., Křížová, E., Šestáková, Š., Vápenková, K., Knejzlík, Z., Rimpelová, S., Rayová, D., Volfová, N., Křížová, I., Rumlová, M., Sýkora, D., Kizek, R., Haluzík, M., Zídek, V., Zídková, J., Škop, V. Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth. Journal of Biological Chemistry. 2019, 294(22), 8676–8689. https://doi.org/10.1074/jbc.ra118.003505

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Vacková, Š., Kikerlová, S., Melenovský, V., Kolář, F., Imig, J. D., Kompanowska-Jezierska, E., Sadowski, J., Červenka, L. Altered Renal Vascular Responsiveness to Vasoactive Agents in Rats with Angiotensin II-Dependent Hypertension and Congestive Heart Failure. Kidney & Blood Pressure Research. 2019, 44(4), 792–809. https://doi.org/10.1159%2F000501688

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Vaněčková, I., Behuliak, M., Hojná, S., Kopkan, L., Kadlecová, M., Zicha, J. Exaggerated blood pressure response to fasudil or nifedipine in hypertensive Ren-2 transgenic rats: role of altered baroreflex. Hypertension Research. 2019, 42(2), 145–154. https://doi.org/10.1038/s41440-018-0146-x

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Vaněčková, I., Hojná, S., Vernerová, Z., Kadlecová, M., Rauchová, H., Kompanowska-Jezierska, E., Vaňourková, Z., Červenka, L., Zicha, J. Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ETA Blockade. Frontiers in physiology. 2019, 10(Sep 18), 1145. https://doi.org/10.3389%2Ffphys.2019.01145

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Zicha, J., Hojná, S., Kopkan, L., Červenka, L., Vaněčková, I. The Absence of Sympathoexcitation During the Development of Hypertension in Cyp1a1 Ren-2 Transgenic Rats. Physiological Research. 2019, 68(2), 329–334. https://doi.org/10.33549/physiolres.934151

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2018

Popelová, A., Kákonová, A., Hrubá, L., Kuneš, J., Maletínská, L., Železná, B. Potential neuroprotective and anti-apoptotic properties of a long-lasting stable analog of ghrelin: an in vitro study using SH-SY5Y cells. Physiological Research. 2018, 67(2), 339–346. https://doi.org/10.33549/physiolres.933761

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IOCB

Kapras, V., Vyklický, V., Buděšínský, M., Císařová, I., Vyklický ml., L., Chodounská, H., Jahn, U. Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor. Organic Letters. 2018, 20(4), 946–949. https://doi.org/10.1021/acs.orglett.7b03838

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IOCB

Krausová, B., Slavíková, B., Nekardová, M., Hubálková, P., Vyklický, V., Chodounská, H., Vyklický ml., L., Kudová, E. Positive Modulators of the N-Methyl-D-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters. Journal of Medicinal Chemistry. 2018, 61(10), 4505–4516. https://doi.org/10.1021/acs.jmedchem.8b00255

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IOCB

Holubová, M., Blechová, M., Kákonová, A., Kuneš, J., Železná, B., Maletínská, L. In Vitro and In Vivo Characterization of Novel Stable Peptidic Ghrelin Analogs: Beneficial Effects in the Settings of Lipopolysaccharide-Induced Anorexia in Mice. Journal of Pharmacology and Experimental Therapeutics. 2018, 366(3), 422–432. https://doi.org/10.1124/jpet.118.249086

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IOCB

Holubová, M., Hrubá, L., Neprašová, B., Majerčíková, Z., Lacinová, Z., Kuneš, J., Maletínská, L., Železná, B. Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice. Journal of Molecular Endocrinology. 2018, 60(2), 85–94. https://doi.org/10.1530/jme-17-0171

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IOCB

Adla, S. K., Slavíková, B., Chodounská, H., Vyklický, V., Ladislav, M., Hubálková, P., Krausová, B., Smejkalová, T., Nekardová, M., Šmídková, M., Monincová, L., Souček, R., Vyklický ml., L., Kudová, E. Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif. Frontiers in Pharmacology. 2018, 9(Nov 12), 1299. https://doi.org/10.3389/fphar.2018.01299

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IOCB

Antošová, Z., Herkommerová, K., Pichová, I., Sychrová, H. Efficient secretion of three fungal laccases from Saccharomyces cerevisiae and their potential for decolorization of textile industry effluent – A comparative study. Biotechnology Progress. 2018, 34(1), 69–80. https://doi.org/10.1002/btpr.2559

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IOCB

Boušová, K., Herman, P., Večeř, J., Bednárová, L., Monincová, L., Majer, P., Vyklický ml., L., Vondrášek, J., Teisinger, J. Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus. FEBS Journal. 2018, 285(3), 599–613. https://doi.org/10.1111/febs.14362

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Herkommerová, K., Dostál, J., Pichová, I. Decolorization and detoxification of textile wastewaters by recombinant Myceliophthora thermophila and Trametes trogii laccases. 3 Biotech. 2018, 8(12), 505. https://doi.org/10.1007%2Fs13205-018-1525-3

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IOCB

Jirátová, M., Pospíšilová, A., Rabyk, M., Pařízek, M., Kovář, J., Gálisová, A., Hrubý, M., Jirák, D. Biological characterization of a novel hybrid copolymer carrier system based on glycogen. Drug Delivery and Translational Research. 2018, 8(1), 73–82. https://doi.org/10.1007/s13346-017-0436-x

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IKEM

Popelová, A., Pražienková, V., Neprašová, B., Kasperová, B. J., Hrubá, L., Holubová, M., Zemenová, J., Blum, D., Železná, B., Galas, M. C., Kuneš, J., Maletínská, L. Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy. Journal of Alzheimer's Disease. 2018, 62(4), 1725–1736. https://doi.org/10.3233/jad-171041

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IOCB

Vyklický, V., Krausová, B., Černý, J., Ladislav, M., Smejkalová, T., Kysilov, B., Kořínek, M., Danačíková, Š., Horák, M., Chodounská, H., Kudová, E., Vyklický ml., L. Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit. Frontiers in Molecular Neuroscience. 2018, 11(Apr 6), 110. https://doi.org/10.3389/fnmol.2018.00110

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Červenka, L., Husková, Z., Kopkan, L., Kikerlová, S., Sedláková, L., Vaňourková, Z., Alánová, P., Kolář, F., Hammock, B.D., Hwang, S.H., Imig, J. D., Falck, J. R., Sadowski, J., Kompanowska-Jezierska, E., Neckář, J. Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension. Journal of Hypertension. 2018, 36(6), 1326–1341. https://doi.org/10.1097/hjh.0000000000001708

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IKEM

Dvořák, J., Švihlík, J., Kybic, J., Radochová, B., Janáček, J., Kukal, J., Borovec, J., Habart, D. Volume estimation from single images: an application to pancreatic islets. Image Analysis and Stereology. 2018, 37(3), 191–204. https://doi.org/10.5566/ias.1869

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IKEM

Krátký, V., Kopkan, L., Kikerlová, S., Husková, Z., Táborský, M., Sadowski, J., Kolář, F., Červenka, L. The Role of Renal Vascular Reactivity in the Development of Renal Dysfunction in Compensated and Decompensated Congestive Heart Failure. Kidney & Blood Pressure Research. 2018, 43(6), 1730–1741. https://doi.org/10.1159/000495391

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IKEM

Mikulášková, B., Holubová, M., Pražienková, V., Zemenová, J., Hrubá, L., Haluzík, M., Železná, B., Kuneš, J., Maletínská, L. Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study. Nutrition & Diabetes. 2018, 8(Jan 16), 5. https://doi.org/10.1038/s41387-017-0015-8

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IKEM

Neckář, J., Hsu, A., Khan, M. A. H., Gross, G. J., Nithipatikom, K., Cyprová, M., Benák, D., Hlaváčková, M., Sotáková-Kašparová, D., Falck, J. R., Sedmera, D., Kolář, F., Imig, J. D. Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3. American Journal of Physiology-Heart and Circulatory Physiology. 2018, 315(5), H1148–H1158. https://doi.org/10.1152/ajpheart.00726.2017

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IKEM

Peševski, Ž., Kvasilová, A., Stopková, T., Naňka, O., Drobná Krejčí, E., Buffinton, C., Kočková, R., Eckhardt, A., Sedmera, D. Endocardial Fibroelastosis is Secondary to Hemodynamic Alterations in the Chick Embryonic Model of Hypoplastic Left Heart Syndrome. Developmental Dynamics. 2018, 247(3), 509–520. https://doi.org/10.1002/dvdy.24521

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Poledne, R., Zicha, J. Human genome evolution and development of cardiovascular risk factors through natural selection. Physiological Research. 2018, 67(2), 155–163. https://doi.org/10.33549/physiolres.933885

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IKEM

Pravenec, M., Saba, L. M., Zídek, V., Landa, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Strnad, H., Trnovská, J., Škop, V., Hüttl, M., Marková, I., Oliyarnyk, O., Malínská, H., Kazdová, L., Smith, H., Tabakoff, B. Systems genetic analysis of brown adipose tissue function. Physiological Genomics. 2018, 50(1), 52–66. https://doi.org/10.1152/physiolgenomics.00091.2017

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IKEM

Rossmeisl, M., Pavlišová, J., Janovská, P., Kuda, O., Bardová, K., Hansíková, J., Svobodová, M., Oseeva, M., Veleba, J., Kopecký Jr., J., Žáček, P., Fišerová, E., Pelikánová, T., Kopecký, J. Differential modulation of white adipose tissue endocannabinoid levels by n-3 fatty acids in obese mice and type 2 diabetic patients. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2018, 1863(7), 712–725. https://doi.org/10.1016/j.bbalip.2018.03.011

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Sedláková, L., Kikerlová, S., Husková, Z., Červenková, L., Čertíková Chábová, V., Zicha, J., Falck, J. R., Imig, J. D., Kompanowska-Jezierska, E., Sadowski, J., Krátký, V., Červenka, L., Kopkan, L. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats. Bioscience Reports. 2018, 38(5), BSR20171496. https://doi.org/10.1042%2FBSR20171496

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IKEM

Straka, F., Schorník, D., Mašín, J., Filová, E., Miřejovský, T., Burdíková, Z., Švindrych, Z., Chlup, H., Horný, L., Daniel, M., Machač, J., Skibová, J., Pirk, J., Bačáková, L. A human pericardium biopolymeric scaffold for autologous heart valve tissue engineering: cellular and extracellular matrix structure and biomechanical properties in comparison with a normal aortic heart valve. Journal of Biomaterial Science Polymer Edition. 2018, 29(6), 599–634. https://doi.org/10.1080/09205063.2018.1429732

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IKEM

Šilhavý, J., Krijt, J., Sokolová, J., Zídek, V., Mlejnek, P., Šimáková, M., Škop, V., Trnovská, J., Oliyarnyk, O., Marková, I., Hüttl, M., Malínská, H., Kazdová, L., Liška, F., Kožich, V., Pravenec, M. Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats. Physiological Research. 2018, 67(4), 657–662. https://doi.org/10.33549/physiolres.933932

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Šilhavý, J., Mlejnek, P., Šimáková, M., Vaněčková, I., Behuliak, M., Kuda, O., Sticová, E., Jirsa, M., Pravenec, M. Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet. Physiological Research. 2018, 67(6), 851–856. https://doi.org/10.33549/physiolres.933951

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IKEM

Vaněčková, I., Hojná, S., Kadlecová, M., Vernerová, Z., Kopkan, L., Červenka, L., Zicha, J. Renoprotective Effects of ET_A Receptor Antagonists Therapy in Experimental Non-Diabetic Chronic Kidney Disease: Is There Still Hope for the Future? Physiological Research. 2018, 67(Suppl.1), S55–S67. https://doi.org/10.33549/physiolres.933898

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2017

Bugáňová, M., Pelantová, H., Holubová, M., Šedivá, B., Maletínská, L., Železná, B., Kuneš, J., Kačer, P., Kuzma, M., Haluzík, M. The effects of liraglutide in mice with diet-induced obesity studied by metabolomics. Journal of Endocrinology. 2017, 233(1), 93–104. https://doi.org/10.1530/joe-16-0478

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IKEM

IOCB

Pražienková, V., Holubová, M., Pelantová, H., Bugáňová, M., Pirník, Z., Mikulášková, B., Popelová, A., Blechová, M., Haluzík, M., Železná, B., Kuzma, M., Kuneš, J., Maletínská, L. Impact of novel palmitoylated prolactin-releasing peptide analogs on metabolic changes in mice with diet-induced obesity. PLoS ONE. 2017, 12(8), e0183449. https://doi.org/10.1371/journal.pone.0183449

IPHYS

IKEM

IOCB

Adla, S. K., Slavíková, B., Šmídková, M., Tloušťová, E., Svoboda, M., Vyklický, V., Krausová, B., Hubálková, P., Nekardová, M., Holubová, K., Valeš, K., Buděšínský, M., Vyklický ml., L., Chodounská, H., Kudová, E. Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors. Steroids. 2017, 117(Jan), 52–61. https://doi.org/10.1016/j.steroids.2016.08.010

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Gibalová, A., Steinbachová, L., Hafidh, S., Bláhová, V., Gadiou, Z., Michailidis, C., Müller, K., Pleskot, R., Dupľáková, N., Honys, D. Characterization of pollen-expressed bZIP protein interactions and the role of ATbZIP18 in the male gametophyte. Plant Reproduction. 2017, 30(1), 1–17. https://doi.org/10.1007/s00497-016-0295-5

IPHYS

IOCB

Kao, H. Y., Dvořák, D., Park, E., Kenney, J., Kelemen, E., Fenton, A.A. Phencyclidine Discoordinates Hippocampal Network Activity But Not Place Fields. Journal of Neuroscience. 2017, 37(49), 12031–12049. https://doi.org/10.1523/jneurosci.0630-17.2017

IPHYS

IOCB

Zemenová, J., Sýkora, D., Maletínská, L., Kuneš, J. Lipopeptides as therapeutics: applications and in vivo quantitative analysis. Bioanalysis. 2017, 9(2), 215–230. https://doi.org/10.4155/bio-2016-0206

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IOCB

Jirák, D., Janáček, J. Volume of the crocodilian brain and endocast during ontogeny. PLoS ONE. 2017, 12(6), e0178491. https://doi.org/10.1371/journal.pone.0178491

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IKEM

Kostiv, U., Rajsiglová, L., Luptáková, D., Pluháček, T., Vannucci, L., Havlíček, V., Engstová, H., Jirák, D., Šlouf, M., Makovický, P., Sedláček, R., Horák, D. Biodistribution of upconversion/magnetic silica-coated NaGdF₄:Yb³⁺/Er³⁺ nanoparticles in mouse models. RSC Advances. 2017, 7(73), 45997–46006. https://doi.org/10.1039/C7RA08712H

IPHYS

IKEM

Liška, F., Landa, V., Zídek, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Strnad, H., Trnovská, J., Škop, V., Kazdová, L., Starker, C.G., Voytas, D.F., Izsvák, Z., Mancini, M., Šeda, O., Křen, V., Pravenec, M. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Hypertension. 2017, 69(6), 1084–1091. https://doi.org/10.1161/hypertensionaha.116.08798

IPHYS

IKEM

Lišková, J., Hadraba, D., Filová, E., Koňařík, M., Pirk, J., Jelen, K., Bačáková, L. Valve interstitial cell culture: Production of mature type I collagen and precise detection. Microscopy Research and Technique. 2017, 80(8), 936–942. https://doi.org/10.1002/jemt.22886

IPHYS

IKEM

Melenovský, V., Petrák, J., Mráček, T., Beneš, J., Borlaug, B. A., Nůsková, H., Pluháček, T., Špatenka, J., Kovalčíková, J., Drahota, Z., Kautzner, J., Pirk, J., Houštěk, J. Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. European Journal of Heart Failure. 2017, 19(4), 522–530. https://doi.org/10.1002/ejhf.640

IPHYS

IKEM

Neckář, J., Svatoňová, A., Weissová, R., Drahota, Z., Zajíčková, P., Brabcová, I., Kolář, D., Alánová, P., Vašinová, J., Šilhavý, J., Hlaváčková, M., Tauchmannová, K., Milerová, M., Ošťádal, B., Červenka, L., Žurmanová, J., Kalous, M., Nováková, O., Novotný, J., Pravenec, M., Kolář, F. Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats. Clinical science. 2017, 131(9), 865–881. https://doi.org/10.1042/cs20170083

IPHYS

IKEM

Pravenec, M., Zídek, V., Landa, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Trnovská, J., Škop, V., Marková, I., Malínská, H., Hüttl, M., Kazdová, L., Bardová, K., Tauchmannová, K., Vrbacký, M., Nůsková, H., Mráček, T., Kopecký, J., Houštěk, J. Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Physiological Research. 2017, 66(6), 917–924. https://doi.org/10.33549/physiolres.933811

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IKEM

Sedláková, L., Čertíková Chábová, V., Doleželová, Š., Škaroupková, P., Kopkan, L., Husková, Z., Červenková, L., Kikerlová, S., Vaněčková, I., Sadowski, J., Kompanowska-Jezierska, E., Kujal, P., Kramer, H. J., Červenka, L. Renin-angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clinical and Experimental Hypertension. 2017, 39(2), 183–195. https://doi.org/10.1080/10641963.2016.1235184

IPHYS

IKEM

Straka, F., Schorník, D., Mašín, J., Filová, E., Miřejovský, T., Burdíková, Z., Švindrych, Z., Chlup, H., Horný, L., Veselý, J., Pirk, J., Bačáková, L. A New Approach to Heart Valve Tissue Engineering Based on Modifying Autologous Human Pericardium by 3D Cellular Mechanotransduction. Journal of Biomaterials and Tissue Engineering. 2017, 7(7), 527–543. https://doi.org/10.1166/jbt.2017.1598

IPHYS

IKEM

Šeda, O., Liška, F., Pravenec, M., Vernerová, Z., Kazdová, L., Křenová, D., Zídek, V., Šedová, L., Krupková, M., Křen, V. Connexin 50 Mutation Lowers Blood Pressure in Spontaneously Hypertensive Rat. Physiological Research. 2017, 66(1), 15–28. https://doi.org/10.33549/physiolres.933432

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IKEM

Špaček, T., Pavluch, V., Alán, L., Capková, N., Engstová, H., Dlasková, A., Berková, Z., Saudek, F., Ježek, P. Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats. Scientific Reports. 2017, 7(Nov 15), 15674. https://doi.org/10.1038/s41598-017-15958-6

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IKEM

Trnovská, J., Šilhavý, J., Kuda, O., Landa, V., Zídek, V., Mlejnek, P., Šimáková, M., Strnad, H., Škop, V., Oliyarnyk, O., Kazdová, L., Haluzík, M., Pravenec, M. Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls. PLoS ONE. 2017, 12(6), e0179063. https://doi.org/10.1371/journal.pone.0179063

IPHYS

IKEM

2016

Kuda, O., Březinová, M., Rombaldová, M., Slavíková, B., Pošta, M., Beier, P., Janovská, P., Veleba, J., Kopecký Jr., J., Kudová, E., Pelikánová, T., Kopecký, J. Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. Diabetes. 2016, 65(9), 2580–2590. https://doi.org/10.2337/db16-0385

IPHYS

IKEM

IOCB

Holubová, M., Zemenová, J., Mikulášková, B., Panajotová, V., Stöhr, J., Haluzík, M., Kuneš, J., Železná, B., Maletínská, L. Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats. Journal of Endocrinology. 2016, 229(2), 85–96. https://doi.org/10.1530/joe-15-0519

IPHYS

IOCB

Jirků, M., Lánský, Z., Bednárová, L., Šulc, M., Monincová, L., Majer, P., Vyklický ml., L., Vondrášek, J., Teisinger, J., Boušová, K. The characterization of a novel S100A1 binding site in the N-terminus of TRPM1. International Journal of Biochemistry and Cell Biology. 2016, 78(Sep 2016), 186–193. https://doi.org/10.1016/j.biocel.2016.07.014

IPHYS

IOCB

Kasal, A., Buděšínský, M., Mareš, P., Krištofíková, Z., Leitao, A. J., Sá e Melo, M. L., Silva, M. M. C. Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group? Steroids. 2016, 105(Jan), 12–18. https://doi.org/10.1016/j.steroids.2015.11.007

IPHYS

IOCB

Kuneš, J., Pražienková, V., Popelová, A., Mikulášková, B., Zemenová, J., Maletínská, L. Prolactin-releasing peptide: a new tool for obesity treatment. Journal of Endocrinology. 2016, 230(2), R51–R58. https://doi.org/10.1530/joe-16-0046

IPHYS

IOCB

Mikulášková, B., Zemenová, J., Pirník, Z., Pražienková, V., Bednárová, L., Železná, B., Maletínská, L., Kuneš, J. Effect of palmitoylated prolactin-releasing peptide on food intake and neural activation after different routes of peripheral administration in rats. Peptides. 2016, 75(Jan), 109–117. https://doi.org/10.1016/j.peptides.2015.11.005

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IOCB

Mikulášková, B., Maletínská, L., Zicha, J., Kuneš, J. The role of food intake regulating peptides in cardiovascular regulation. Molecular and Cellular Endocrinology. 2016, 436(Nov 15), 78–92. https://doi.org/10.1016/j.mce.2016.07.021

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IOCB

Kirubakaran, P., Pfeiferová, L., Boušová, K., Bednárová, L., Obšilová, V., Vondrášek, J. Artificial proteins as allosteric modulators of PDZ3 and SH3 in two-domain constructs: A computational characterization of novel chimeric proteins. Proteins-Structure, Function and Bioinformatics. 2016, 84(10), 1358–1374. https://doi.org/10.1002/prot.25082

IPHYS

IOCB

Pelantová, H., Bugáňová, M., Holubová, M., Šedivá, B., Zemenová, J., Sýkora, D., Kaválková, P., Haluzík, M., Železná, B., Maletínská, L., Kuneš, J., Kuzma, M. Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination. Molecular and Cellular Endocrinology. 2016, 431(C), 88–100. https://doi.org/10.1016/j.mce.2016.05.003

IPHYS

IOCB

Slavíková, B., Chodounská, H., Nekardová, M., Vyklický, V., Ladislav, M., Hubálková, P., Krausová, B., Vyklický ml., L., Kudová, E. Neurosteroid-like Inhibitors of N-Methyl-D-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene. Journal of Medicinal Chemistry. 2016, 59(10), 4724–4739. https://doi.org/10.1021/acs.jmedchem.6b00079

IPHYS

IOCB

Vyklický, V., Smejkalová, T., Krausová, B., Balík, A., Kořínek, M., Borovská, J., Horák, M., Chvojková, M., Kletečková, L., Valeš, K., Černý, J., Nekardová, M., Chodounská, H., Kudová, E., Vyklický ml., L. Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives. Journal of Neuroscience. 2016, 36(7), 2161–2175. https://doi.org/10.1523/JNEUROSCI.3181-15.2016

IPHYS

IOCB

Jíchová, Š., Kopkan, L., Husková, Z., Doleželová, Š., Neckář, J., Kujal, P., Vernerová, Z., Kramer, H. J., Sadowski, J., Kompanowska-Jezierska, E., Reddy, N. R., Falck, J. R., Imig, J. D., Červenka, L. Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. Journal of Hypertension. 2016, 34(10), 2008–2025. https://doi.org/10.1097%2FHJH.0000000000001029

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IKEM

Kočková, R., Kačer, P., Pirk, J., Malý, J., Sukupová, L., Sikula, V., Kotrc, M., Barciaková, L., Honsová, E., Malý, M., Kautzner, J., Sedmera, D., Penicka, M. Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy. Circulation Journal. 2016, 80(5), 1202–1209. https://doi.org/10.1253/circj.cj-15-1309

IPHYS

IKEM

Malínská, H., Oliyarnyk, O., Škop, V., Šilhavý, J., Landa, V., Zídek, V., Mlejnek, P., Šimáková, M., Strnad, H., Kazdová, L., Pravenec, M. Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein. PLoS ONE. 2016, 11(3), e0150924. https://doi.org/10.1371%2Fjournal.pone.0150924

IPHYS

IKEM

Pravenec, M., Kožich, V., Krijt, J., Sokolová, J., Zídek, V., Landa, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Škop, V., Trnovská, J., Kazdová, L., Kajiya, T., Wang, J. M., Kurtz, T. W. Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome. Hypertension. 2016, 67(2), 335–341. https://doi.org/10.1161/hypertensionaha.115.06158

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IKEM

Pravenec, M., Mlejnek, P., Zídek, V., Landa, V., Šimáková, M., Šilhavý, J., Strnad, H., Eigner, S., Eigner-Henke, K., Škop, V., Malínská, H., Trnovská, J., Kazdová, L., Drahota, Z., Mráček, T., Houštěk, J. Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue. Physiological Genomics. 2016, 48(6), 420–427. https://doi.org/10.1152/physiolgenomics.00122.2015

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IKEM

Rambousek, L., Kletečková, L., Kubesová, A., Jirák, D., Valeš, K., Fritschy, J.M. Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABA_A receptor subunits. Neuropharmacology. 2016, 105(Jun), 594–606. https://doi.org/10.1016/j.neuropharm.2016.02.035

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IKEM

Sedmera, D., Neckář, J., Beneš Jr., J., Pospíšilová, J., Petrák, J., Sedláček, K., Melenovský, V. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload. Frontiers in physiology. 2016, 7(Aug 25), 367. https://doi.org/10.3389/fphys.2016.00367

IPHYS

IKEM

Šedová, L., Pravenec, M., Křenová, D., Kazdová, L., Zídek, V., Krupková, M., Liška, F., Křen, V., Šeda, O. Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model. PLoS ONE. 2016, 11(3), e0152708. https://doi.org/10.1371%2Fjournal.pone.0152708

IPHYS

IKEM

Škop, V., Trnovská, J., Oliyarnyk, O., Marková, I., Malínská, H., Kazdová, L., Zídek, V., Landa, V., Mlejnek, P., Šimáková, M., Kůdela, M., Pravenec, M., Šilhavý, J. Hepatotoxic effects of fenofibrate in spontaneously hypertensive rats expressing human C-reactive protein. Physiological Research. 2016, 65(6), 891–899. https://doi.org/10.33549/physiolres.933304

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2015

Boušová, K., Jirků, M., Bumba, L., Bednárová, L., Šulc, M., Franěk, M., Vyklický ml., L., Vondrášek, J., Teisinger, J. PIP₂ and PIP₃ interact with N-terminus region of TRPM₄ channel. Biophysical Chemistry. 2015, 205(Oct 2015), 24–32. https://doi.org/10.1016/j.bpc.2015.06.004

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IOCB

Jirků, M., Bumba, L., Bednárová, L., Kubala, M., Šulc, M., Franěk, M., Vyklický ml., L., Vondrášek, J., Teisinger, J., Boušová, K. Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel. Biophysical Chemistry. 2015, 207(Dec), 135–142. https://doi.org/10.1016/j.bpc.2015.10.005

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IOCB

Kudová, E., Chodounská, H., Slavíková, B., Buděšínský, M., Nekardová, M., Vyklický, V., Krausová, B., Švehla, P., Vyklický ml., L. A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications. Journal of Medicinal Chemistry. 2015, 58(15), 5950–5966. https://doi.org/10.1021/acs.jmedchem.5b00570

IPHYS

IOCB

Kuneš, J., Vaněčková, I., Mikulášková, B., Behuliak, M., Maletínská, L., Zicha, J. Epigenetics and a new look on metabolic syndrome. Physiological Research. 2015, 64(5), 611–620. https://doi.org/10.33549/physiolres.933174

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IOCB

Maletínská, L., Nagelová, V., Tichá, A., Zemenová, J., Pirník, Z., Holubová, M., Špolcová, A., Mikulášková, B., Blechová, M., Sýkora, D., Lacinová, Z., Haluzík, M., Železná, B., Kuneš, J. Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration. International Journal of Obesity. 2015, 39(6), 986–993. https://doi.org/10.1038/ijo.2015.28

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IOCB

Vyklický, V., Krausová, B., Černý, J., Balík, A., Zápotocký, M., Novotný, M., Lichnerová, K., Smejkalová, T., Kaniaková, M., Kořínek, M., Petrovič, M., Kačer, P., Horák, M., Chodounská, H., Vyklický ml., L. Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule. Scientific Reports. 2015, 5(Jun 18), 10935. https://doi.org/10.1038/srep10935

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IOCB

Alán, L., Olejár, T., Cahová, M., Zelenka, J., Berková, Z., Smětáková, M., Saudek, F., Matěj, R., Ježek, P. Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats. Journal of Diabetes Research. 2015, 2015(2015), 385395. https://doi.org/10.1155%2F2015%2F385395

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IKEM

Alánová, P., Husková, Z., Kopkan, L., Sporková, A., Jíchová, Š., Neckář, J., Imig, J. D., Klevstig, M., Kolář, F., Reddy, N. R., Falck, J. R., Sadowski, J., Nishiyama, A., Kramer, H. J., Melenovský, V., Červenková, L., Kujal, P., Vernerová, Z., Červenka, L. Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats. Vascular Pharmacology. 2015, 73(Oct 2015), 45–56. https://doi.org/10.1016/j.vph.2015.08.013

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IKEM

Cahová, M., Chrastina, P., Hansíková, H., Drahota, Z., Trnovská, J., Škop, V., Spáčilová, J., Malínská, H., Oliyarnyk, O., Papáčková, Z., Páleníčková, E., Kazdová, L. Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats. Applied Physiology Nutrition and Metabolism-Physiologie appliquee nutrition et metabolisme. 2015, 40(3), 280–291. https://doi.org/10.1139/apnm-2014-0163

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IKEM

Cahová, M., Páleníčková, E., Danková, H., Sticová, E., Burian, M., Drahota, Z., Červinková, Z., Kučera, O., Gladkova, C., Stopka, P., Křížová, J., Papáčková, Z., Oliyarnyk, O., Kazdová, L. Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2015, 309(2), G100–G111. https://doi.org/10.1152/ajpgi.00329.2014

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IKEM

Chytilová, A., Borchert, G. H., Mandíková-Alánová, P., Hlaváčková, M., Kopkan, L., Khan, M. A. H., Imig, J. D., Kolář, F., Neckář, J. Tumour necrosis factor-α contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia. Acta Physiologica. 2015, 241(1), 97–108. https://doi.org/10.1111/apha.12489

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IKEM

Jirák, D., Janáček, J., Kear, B. P. A combined MR and CT study for precise quantitative analysis of the avian brain. Scientific Reports. 2015, 5(Oct 30), 16002. https://doi.org/10.1038/srep16002

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Trnovská, J., Šilhavý, J., Zídek, V., Šimáková, M., Mlejnek, P., Landa, V., Eigner, S., Eigner-Henke, K., Škop, V., Oliyarnyk, O., Kazdová, L., Mráček, T., Houštěk, J., Pravenec, M. Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat. Physiological Research. 2015, 64(1), 51–60. https://doi.org/10.33549/physiolres.932823

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Veleba, J., Kopecký Jr., J., Janovská, P., Kuda, O., Horáková, O., Malínská, H., Kazdová, L., Oliyarnyk, O., Škop, V., Trnovská, J., Hájek, M., Škoch, A., Flachs, P., Bardová, K., Rossmeisl, M., Olza, J., de Castro, S. G., Calder, P. C., Gardlo, A., Fišerová, E., Jensen, J., Bryhn, M., Kopecký, J., Pelikánová, T. Combined intervention with pioglitazone and n-3 fatty acids in metformin-treated type 2 diabetic patients: improvement of lipid metabolism. Nutrition & Metabolism. 2015, 12(Dec 2), 52. https://doi.org/10.1186%2Fs12986-015-0047-9

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Sedmera, D., Kočková, R., Vostárek, F., Raddatz, E. Arrhythmias in the developing heart. Acta Physiologica. 2015, 213(2), 303–320. https://doi.org/10.1111/apha.12418

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