Diabetes mellitus is a disease resulting from a long-term increase in blood sugar levels. If diabetes is not treated adequately, elevated blood sugar levels can lead to serious complications, namely an increased risk of cardiovascular diseases, shortened life expectancy, and damage to the eyes, nerves, and kidneys. The most common form of diabetes is type 2, which typically occurs in middle-aged and older individuals and is associated with an unhealthy lifestyle, obesity, arterial hypertension, and lipid metabolism disorders. In the Czech Republic, nearly 10% of the population currently suffers from diabetes. The cost of treating the disease accounts for 15–20% of the overall cost of healthcare, two thirds of which is spent on treating chronic complications. The goal of the collaboration between IKEM, IOCB, and IPHYS is the development of new drugs with a comprehensive effect on diabetic compensation and diabetes-related diseases that can facilitate prevention and provide effective therapy.
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