MediAim

Our publications

Joint papers of IKEM, IOCB, and IPHYS researchers

Search citations:
Filter by year:
Filter by institution:
Search citations:
Filter by year:
Filter by institution:

2024

Charvát, V., Strnadová, A., Myšková, A., Sýkora, D., Blechová, M., Železná, B., Kuneš, J., Maletínská, L., Pačesová, A. Lipidized analogues of the anorexigenic CART (cocaine- and amphetamine-regulated transcript) neuropeptide show anorexigenic and neuroprotective potential in mouse model of monosodium-glutamate induced obesity. European Journal of Pharmacology. 2024, 980(5 October), 176864. https://doi.org/10.1016/j.ejphar.2024.176864
IPHYS
IOCB
Mrázková, L., Lubos, M., Voldřich, J., Kužmová, E., Zrubecká, D., Gwozdiaková, P., Buděšínský, M., Asai, S., Marek, A., Pícha, J., Tencerová, M., Ferenčáková, M., Barrera Alquicer, G., Kaminský, J., Jiráček, J., Žáková, L. The final walk with preptin. PLoS ONE. 2024, 19(9), e0309726. https://doi.org/10.1371/journal.pone.0309726
IPHYS
IOCB

Bačáková, L., Chlupáč, J., Filová, E., Musílková, J., Tomšů, J., Wu, Y., Svobodová, L., Pražák, Š., Brož, A. Vascular Damage and Repair, Are Small-Diameter Vascular Grafts Still the “Holy Grail” of Tissue Engineering? Physiological Research. 2024, 73(Suppl.1), S335–S363. https://doi.org/10.33549/physiolres.935294

IPHYS
IKEM
Rauchová, H., Neprašová, B., Maletínská, L., Kuneš, J. Glutathione Levels and Lipid Oxidative Damage in Selected Organs of Obese Koletsky and Lean Spontaneously Hypertensive Rats. Physiological Research. 2024, 73(3), 481–484. https://doi.org/10.33549/physiolres.935319 
IPHYS
IOCB
Kasperová, B. J., Mráz, M., Svoboda, P., Hlaváček, D., Kratochvílová, H., Modos, I., Vrzáčková, N., Ivák, P., Janovská, P., Kobets, T., Mahrík, J., Riečan, M., Steiner Mrázová, L., Stránecký, V., Netuka, I., Čajka, T., Kuda, O., Melenovský, V., Štemberková-Hubáčková, S., Haluzík, M. Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure. Cardiovascular Diabetology. 2024, 23(1), 223. https://doi.org/10.1186/s12933-024-02298-9
IPHYS
IKEM
Jadhav, S. B., Vondráčková, M., Potomova, P., Sandoval-Acuna, C., Šmigová, J., Klanicova, K., Rosel, D., Brabek, J., Štursa, J., Werner, L., Truksa, J. NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation. Frontiers in Pharmacology. 2024, 15(JUN 25 2024), 1422369. https://doi.org/10.3389/fphar.2024.1422369
IPHYS
IKEM
Marhefková, N., Sládek, M., Sumová, A., Dubský, M. Circadian dysfunction and cardio-metabolic disorders in humans. Frontiers in Endocrinology. 2024, 15(29 April), 1328139. https://doi.org/10.3389/fendo.2024.1328139
IPHYS
IKEM
Němečková, I., Eissazadeh, S., Rathouská Urbánková, J., Šilhavý, J., Malínská, H., Pravenec, M., Nachtigal, P. Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats. BMC Cardiovascular Disorders. 2024, 24(1), 211. https://doi.org/10.1186/s12872-024-03870-7
IPHYS
IKEM
Hojná, S., Malínská, H., Hüttl, M., Vaňourková, Z., Marková, I., Miklánková, D., Hrdlička, J., Papoušek, F., Neckář, J., Kujal, P., Behuliak, M., Rauchová, H., Kadlecová, M., Sedmera, D., Neffeová, K., Zábrodská, E., Olejníčková, V., Zicha, J., Vaněčková, I. Hepatoprotective and cardioprotective effects of empagliflozin in spontaneously hypertensive rats fed a high-fat diet. Biomedicine & Pharmacotherapy. 2024, 174(May), 116520. https://doi.org/10.1016/j.biopha.2024.116520
IPHYS
IKEM
Strnadová, V., Pačesová, A., Charvát, V., Šmotková, Z., Železná, B., Kuneš, J., Maletínská, L. Anorexigenic neuropeptides as anti-obesity and neuroprotective agents: exploring the neuroprotective effects of anorexigenic neuropeptides. Bioscience Reports. 2024, 44(4), BSR20231385. https://doi.org/10.1042/BSR20231385
IPHYS
IOCB
Strnadová, V., Morgan, A., Škrlová, M., Haasová, E., Bardová, K., Myšková, A., Sýkora, D., Kuneš, J., Železná, B., Maletínská, L. Peripheral administration of lipidized NPAF and NPFF analogs does not influence central food intake regulation but induces anxiety-like behavior. Neuropeptides. 2024, 104(April), 102417. https://doi.org/10.1016/j.npep.2024.102417
IPHYS
IOCB
Šuca, H., Čoma, M., Tomšů, J., Sabová, J., Zajíček, R., Brož, A., Doubková, M., Novotný, T., Bačáková, L., Jenčová, V., Kuželová Košťáková, E., Lukačín, Š., Rejman, D., Gál, P. Current Approaches to Wound Repair in Burns: How far we Have Come From Cover to Close? A Narrative Review. Journal of Surgical Research. 2024, 296(April), 383–403. https://doi.org/10.1016/j.jss.2023.12.043
IPHYS
IOCB
Cheema, M. M., Kotrbová Macáková, Z., Hrčka Krausová, B., Adla, S. K., Slavíková, B., Chodounská, H., Kratochvíl, M., Vondrášek, J., Sedlák, D., Balaštík, M., Kudová, E. 5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia. Journal of Steroid Biochemistry and Molecular Biology. 2024, 239(May), 106464. https://doi.org/10.1016/j.jsbmb.2024.106464
IPHYS
IOCB
Kysilov, B., Kuchtiak, V., Hrčka Krausová, B., Balík, A., Kořínek, M., Fili, K., Dobrovolski, M., Abramová, V., Chodounská, H., Kudová, E., Božíková, P., Černý, J., Smejkalová, T., Vyklický ml., L. Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids. Cellular and Molecular Life Sciences. 2024, 81(1), 36. https://doi.org/10.1007/s00018-023-05062-6
IPHYS
IOCB
Šilhavý, J., Mlejnek, P., Šimáková, M., Liška, F., Malínská, H., Marková, I., Hüttl, M., Miklánková, D., Mušálková, D., Stránecký, V., Kmoch, S., Sticová, E., Vrbacký, M., Mráček, T., Pravenec, M. Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat. Physiological Genomics. 2024, B(1), 65–73. https://doi.org/10.1152/physiolgenomics.00084.2023
IPHYS
IKEM

2023

Železná, B., Pačesová, A., Strnadová, V., Kuneš, J., Maletínská, L. Peptid uvolňující prolaktin: neuropeptid s nevhodným jménem, ale vhodnými vlastnostmi pro léčbu obezity, diabetu 2. typu i Alzheimerovy nemoci. Chemické listy. 2023, 117(12), 732–738. https://doi.org/10.54779/chl20230732
IPHYS
IOCB
Myšková, A., Sýkora, D., Kuneš, J., Maletínská, L. Lipidization as a tool toward peptide therapeutics. Drug Delivery. 2023, 30(1), 2284685. https://doi.org/10.1080/10717544.2023.2284685
IPHYS
IOCB
Holá, L., Tureckiová, T., Kuneš, J., Železná, B., Maletínská, L. High-Fat Diet Induces Resistance to Ghrelin and LEAP2 Peptide Analogs in Mice. Physiological Research. 2023, 72(5), 607–619. https://doi.org/10.33549/physiolres.935189
IPHYS
IOCB
Mengr, A., Strnadová, V., Strnad, Š., Vrkoslav, V., Pelantová, H., Kuzma, M., Comptdaer, T., Železná, B., Kuneš, J., Galas, M. C., Pačesová, A., Maletínská, L. Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice. Nutrients. 2023, 15(17), 3690. https://doi.org/10.3390/nu15173690
IPHYS
IOCB
Potalitsyn, P., Mrázková, L., Selicharová, I., Tencerová, M., Ferenčáková, M., Chrudinová, M., Turnovská, T., Brzozowski, A. M., Marek, A., Kaminský, J., Jiráček, J., Žáková, L. Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2. Communications Biology. 2023, 6, 863. https://doi.org/10.1038/s42003-023-05239-6
IPHYS
IOCB
Sivčev, S., Kudová, E., Zemková, H. Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective. Neuropharmacology. 2023, 234(Aug 15), 109542. https://doi.org/10.1016/j.neuropharm.2023.109542
IPHYS
IOCB
Piťha, J., Vaněčková, I., Zicha, J. Hypertension after the Menopause: What Can We Learn from Experimental Studies? Physiological Research. 2023, 72(Suppl.2), 91–112. https://doi.org/10.33549/physiolres.935151
IPHYS
IKEM
Kuneš, J., Hojná, S., Mráziková, L., Montezano, A., Touyz, R. M., Maletínská, L. Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms. Physiological Research. 2023, 72(Suppl.2), 73–90. https://doi.org/10.33549/physiolres.935109
IPHYS
IOCB
Plecitá-Hlavatá, L., Brázdová, A., Křivonosková, M., Hu, Ch.-J., Phang, T., Tauber, J., Li, M., Zhang, H., Hoetzenecker, K., Crnkovic, S., Kwapiszewska, G., Stenmark, K. R. Microenvironmental regulation of T-cells in pulmonary hypertension. Frontiers in Immunology. 2023, 14(Jul 11), 1223122. https://doi.org/10.3389/fimmu.2023.1223122
IPHYS
IOCB
Kortus, Š., Řeháková, K., Klíma, M., Kolcheva, M., Ladislav, M., Langore, E., Baráčková, P., Netolický, J., Misiachna, A., Hemelíková, K., Humpolíčková, J., Chalupská, D., Šilhán, J., Kaniaková, M., Hrčka Krausová, B., Bouřa, E., Zápotocký, M., Horák, M. Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes. Journal of Neuroscience. 2023, 43(26), 4755–4774. https://doi.org/10.1523/jneurosci.2014-22.2023
IPHYS
IOCB
Freitas-Lima, L. C., Pačesová, A., Staňurová, J., Šácha, P., Marek, A., Hubálek, M., Kuneš, J., Železná, B., Maletínská, L. GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript peptide. European Journal of Pharmacology. 2023, 949(15 June), 175713. https://doi.org/10.1016/j.ejphar.2023.175713
IPHYS
IOCB
Husková, Z., Kikerlová, S., Miklovič, M., Kala, P., Papoušek, F., Neckář, J. Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension. Frontiers in Physiology. 2023, 14(14 June), 1151308. https://doi.org/10.3389/fphys.2023.1151308
IPHYS
IKEM
Karnošová, A., Strnadová, V., Železná, B., Kuneš, J., Kašpárek, P., Maletínská, L. NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose. Clinical science. 2023, 137(10), 847–862. https://doi.org/10.1042/cs20220880
IPHYS
IOCB
Abramová, V., Alvarado, V. L., Hill, M., Smejkalová, T., Malý, M., Valeš, K., Dittert, I., Božíková, P., Kysilov, B., Hrčka Krausová, B., Vyklický, V., Balík, A., Fili, K., Kořínek, M., Chodounská, H., Kudová, E., Číž, D., Martinovič, J., Bartůněk, P., Vyklický ml., L. Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior. ACS Chemical Neuroscience. 2023, 14(10), 1870–1883. https://doi.org/10.1021/acschemneuro.3c00131
IPHYS
IOCB
Rehák Bučková, B., Kala, D., Kořenek, J., Matušková, V., Kumpošt, V., Svobodová, L., Otáhal, J., Škoch, A., Šulc, V., Olšerová, A., Vyhnálek, M., Janský, P., Tomek, A., Marusič, P., Jiruška, P., Hlinka, J. Structural connectivity-based predictors of cognitive impairment in stroke patients attributable to aging. PLoS ONE. 2023, 18(4), e0280892. https://doi.org/10.1371/journal.pone.0280892
IPHYS
IKEM
Šilhavý, J., Mlejnek, P., Šimáková, Miroslava, Marková, I., Malínská, H., Hüttl, M., Kazdová, L., Kazantsev, D., Mancini, M., Novotný, J., Pravenec, M. CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study. PLoS ONE. 2023, 18(4), e0283276. https://doi.org/10.1371/journal.pone.0283276
IPHYS
IKEM
Pelantová, H., Tomášová, P., Šedivá, B., Neprašová, B., Mráziková, L., Kuneš, J., Železná, B., Maletínská, L., Kuzma, M. Metabolomic Study of Aging in fa/fa Rats: Multiplatform Urine and Serum Analysis. Metabolites. 2023, 13(4), 552. https://doi.org/10.3390/metabo13040552
IPHYS
IOCB
Hüttl, M., Marková, I., Miklánková, D., Zapletalová, I., Kujal, P., Šilhavý, J., Pravenec, M., Malínská, H. Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model. Frontiers in Pharmacology. 2023, 14(3 Apr), 1117683. https://doi.org/10.3389/fphar.2023.1117683
IPHYS
IKEM
Strnadová, V., Karnošová, A., Blechová, M., Neprašová, B., Holá, L., Němcová, A., Myšková, A., Sýkora, D., Železná, B., Kuneš, J., Maletínská, L. Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies. Neuropeptides. 2023, 98(April), 102319. https://doi.org/10.1016/j.npep.2022.102319
IPHYS
IOCB
Habart, D., Koza, A., Leontovyč, I., Kosinová, L., Berková, Z., Kříž, J., Zacharovová, K., Brinkhof, B., Cornelissen, D. J., Magrane, N., Bittenglová, K., Čapek, M., Valečka, J., Habartová, A., Saudek, F. IsletSwipe, a mobile platform for expert opinion exchange on islet graft images. Islets. 2023, 15(1), 2189873. https://doi.org/10.1080/19382014.2023.2189873
IPHYS
IKEM
IOCB
Kynčl, M., Holubová, Z., Tintěra, J., Profantová, N., Šanda, J., Kala, D., Prysiazhniuk, Y., Kudr, M., Kršek, P., Kalina, A., Zárubová, J., Komárek, V., Otáhal, J., Marusič, P. Doporučení pro strukturální zobrazení MR mozku v diagnostice epilepsie. Česká a Slovenská neurologie a neurochirurgie. 2023, 86(1), 18–24
IPHYS
IKEM
Kala, P., Vaňourková, Z., Škaroupková, P., Kompanowska, J., E., Sadowski, J., Walkowska, A., Veselka, J., Táborský, M., Maxová, H., Vaněčková, I., Červenka, L. Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula. Biomedicine & Pharmacotherapy. 2023, 158(February), 114157. https://doi.org/10.1016/j.biopha.2022.114157
IPHYS
IKEM
Šilhavý, J., Mlejnek, P., Šimáková, M., Malínská, H., Marková, I., Hüttl, M., Miklánková, D., Kazdová, L., Vrbacký, M., Pecinová, A., Mráček, T., Pravenec, M. Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome. Metabolites. 2023, 13(2), 192. https://doi.org/10.3390/metabo13020192
IPHYS
IKEM
Mráziková, L., Hojná, S., Vaculová, P., Strnad, Š., Vrkoslav, V., Pelantová, H., Kuzma, M., Železná, B., Kuneš, J., Maletínská, L. Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance. Nutrients. 2023, 15(2), 280. https://doi.org/10.3390/nu15020280
IPHYS
IOCB
Szczurowska, E., Szánti-Pintér, E., Chetverikov, N., Randáková, A., Kudová, E., Jakubík, J. Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids. International Journal of Molecular Sciences. 2023, 24(1), 507. https://doi.org/10.3390/ijms24010507
IPHYS
IOCB
Kolcheva, M., Ladislav, M., Netolický, J., Kortus, Š., Řeháková, K., Hrčka Krausová, B., Hemelíková, K., Misiachna, A., Kádková, A., Klíma, M., Chalupská, D., Horák, M. The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors. Neuropharmacology. 2023, 222(1 January), 109297. https://doi.org/10.1016/j.neuropharm.2022.109297
IPHYS
IOCB
Kala, P., Gawrys, O., Miklovic, M., Vaňourková, Z., Škaroupková, P., Jíchová, Š., Sadowski, J., Kompanowska, J., E., Walkowska, A., Veselka, J., Táborský, M., Maxová, H., Vaněčková, I., Červenka, L. Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension. Journal of Hypertension. 2023, 41(1), 99–114. https://doi.org/10.1097/hjh.0000000000003307
IPHYS
IKEM

2022

Holá, L., Železná, B., Karnošová, A., Kuneš, J., Fehrentz, J. A., Denoyelle, S., Cantel, S., Blechová, M., Sýkora, D., Myšková, A., Maletínská, L. A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin. Journal of Pharmacology and Experimental Therapeutics. 2022, 383(2), 129–136. https://doi.org/10.1124/jpet.122.001322
IPHYS
IOCB
Szczurowska, E., Szánti-Pintér, E., Randáková, A., Jakubík, J., Kudová, E. Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids. International Journal of Molecular Sciences. 2022, 23(21), 13075. https://doi.org/10.3390/ijms232113075
IPHYS
IOCB
Hojná, S., Kotsaridou, Z., Vaňourková, Z., Rauchová, H., Behuliak, M., Kujal, P., Kadlecová, M., Zicha, J., Vaněčková, I. Empagliflozin Is Not Renoprotective in Non-Diabetic Rat Models of Chronic Kidney Disease. Biomedicines. 2022, 10(10), 2509. https://doi.org/10.3390/biomedicines10102509
IPHYS
IKEM
Pačesová, A., Holubová, M., Hrubá, L., Strnadová, V., Neprašová, B., Pelantová, H., Kuzma, M., Železná, B., Kuneš, J., Maletínská, L. Age-related metabolic and neurodegenerative changes in SAMP8 mice. Aging. 2022, 14(18), 7300–7327. https://doi.org/10.18632/aging.204284
IPHYS
IOCB
Malínská, H., Hüttl, M., Marková, I., Miklánková, D., Hojná, S., Papoušek, F., Šilhavý, J., Mlejnek, P., Zicha, J., Hrdlička, J., Pravenec, M., Vaněčková, I. Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein. Biomedicines. 2022, 10(9), 2066. https://doi.org/10.3390/biomedicines10092066
IPHYS
IKEM
Mráziková, L., Hojná, S., Pačesová, A., Hrubá, L., Strnadová, V., Neprašová, B., Železná, B., Kuneš, J., Maletínská, L. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances. Nutrition & Diabetes. 2022, 12(1), 26. https://doi.org/10.1038/s41387-022-00205-3
IPHYS
IOCB
Oeckl, J., Janovská, P., Adamcová, K., Bardová, K., Brunner, S., Dieckmann, S., Ecker, J., Fromme, T., Funda, J., Gantert, T., Giansanti, P., Soledad Hidrobo, M., Kuda, O., Kuster, B., Li, Y., Pohl, R., Schmitt, S., Schweizer, S., Zischka, H., Zouhar, P., Kopecký, J., Klingenspor, M. Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Molecular Metabolism. 2022, 61(July), 101499. https://doi.org/10.1016/j.molmet.2022.101499
IPHYS
IOCB
Shapoval, O., Engstová, H., Jirák, D., Drahokoupil, J., Sulková, K., Berková, Z., Pop-Georgievski, O., Holendová, B., Ježek, P., Horák, D. Poly(4-Styrenesulfonic Acid-co-maleic Anhydride)-Coated NaGdF4:Yb,Tb,Nd Nanoparticles with Luminescence and Magnetic Properties for Imaging of Pancreatic Islets and β-Cells. ACS Applied Materials and Interfaces. 2022, 14(16), 18233–18247. https://doi.org/10.1021/acsami.2c04274
IPHYS
IKEM
Mandal, R., Kohoutová, K., Petrvalská, O., Horváth, M., Srb, P., Veverka, V., Obšilová, V., Obšil, T. FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA. Protein Science. 2022, 31(5), e4287. https://doi.org/10.1002/pro.4287
IPHYS
IOCB
Kysilov, B., Hrčka Krausová, B., Vyklický, V., Smejkalová, T., Kořínek, M., Horák, M., Chodounská, H., Kudová, E., Černý, J., Vyklický ml., L. Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations. British Journal of Pharmacology. 2022, 179(15), 3970–3990. https://doi.org/10.1111/bph.15841
IPHYS
IOCB
Senko, A. N., Overall, R. W., Šilhavý, J., Mlejnek, P., Malínská, H., Hüttl, M., Marková, I., Fabel, K. S., Lu, L., Stuchlík, A., Williams, R. W., Pravenec, M., Kempermann, G. Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose. PLoS Genetics. 2022, 18(4), e1009638. https://doi.org/10.1371/journal.pgen.1009638
IPHYS
IKEM
Chlupáč, J., Matějka, R., Koňařík, M., Novotný, R., Šimůnková, Z., Mrázová, I., Fabian, O., Zapletal, M., Pulda, Z., Lipenský, J. F., Štěpanovská, J., Hanzálek, K., Brož, A., Novák, T., Lodererová, A., Voska, L., Adla, T., Froněk, J., Rozkot, M., Forostyak, S., Kneppo, P., Bačáková, L., Pirk, J. Vascular Remodeling of Clinically Used Patches and Decellularized Pericardial Matrices Recellularized with Autologous or Allogeneic Cells in a Porcine Carotid Artery Model. International Journal of Molecular Sciences. 2022, 23(6), 3310. https://doi.org/10.3390/ijms23063310
IPHYS
IKEM
Magalhaes-Novais, S., Blecha, J., Naraine, R., Mikesova, J., Abaffy, P., Pecinová, A., Miloševič, M., Bohuslavová, R., Procházka, J., Khan, S., Novotná, E., Šindelka, R., Machan, R., Dewerchin, M., Vlčák, E., Kalucka, J., Štemberková-Hubáčková, S., Benda, A., Goveia, J., Mráček, T., Bařinka, C., Carmeliet, P., Neužil, J., Rohlenová, K., Rohlena, J. Mitochondrial respiration supports autophagy to provide stress resistance during quiescence. Autophagy. 2022, 2022–03-21(MAR 2022). https://doi.org/10.1080/15548627.2022.2038898
IPHYS
IKEM
Šilhavý, J., Mlejnek, P., Šimáková, M., Liška, F., Kubovčiak, J., Sticová, E., Pravenec, M. Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension. Biomedicines. 2022, 10(2), 376. https://doi.org/10.3390%2Fbiomedicines10020376
IPHYS
IKEM

Kudová, E., Mareš, P., Hill, M., Vondráková, K., Tsenov, G., Chodounská, H., Kubová, H., Valeš, K. The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains. Pharmaceuticals. 2022, 15(1), 49. https://doi.org/10.3390/ph15010049

IPHYS
IOCB
Imig, J. D., Červenka, L., Neckář, J. Epoxylipids and soluble epoxide hydrolase in heart diseases. Biochemical Pharmacology. 2022, 195(Jan), 114866. https://doi.org/10.1016/j.bcp.2021.114866
IPHYS
IKEM

2021

Pravenec, M., Šilhavý, J., Mlejnek, P., Šimáková, M., Mráček, T., Pecinová, A., Tauchmannová, K., Hüttl, M., Malínská, H., Kazdová, L., Neckář, J., Kolář, F., Žurmanová, J., Novotný, J., Houštěk, J. Conplastic Strains for Identification of Retrograde Effects of Mitochondrial DNA Variation on Cardiometabolic Traits in the Spontaneously Hypertensive Rat. Physiological Research. 2021, 70(Suppl.4), S471–S481. https://doi.org/10.33549%2Fphysiolres.934740
IPHYS
IKEM
Mráziková, L., Neprašová, B., Mengr, A., Popelová, A., Strnadová, V., Holá, L., Železná, B., Kuneš, J., Maletínská, L. Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models. Frontiers in Pharmacology. 2021, 12(Nov 18), 779962. https://doi.org/10.3389/fphar.2021.779962
IPHYS
IOCB
Hüttl, M., Marková, I., Miklánková, D., Zapletalová, I., Poruba, M., Haluzík, M., Vaněčková, I., Malínská, H. In a Prediabetic Model, Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia. International Journal of Molecular Sciences. 2021, 22(21), 11513. https://doi.org/10.3390%2Fijms222111513
IPHYS
IKEM
Hojná, S., Rauchová, H., Malínská, H., Marková, I., Hüttl, M., Papoušek, F., Behuliak, M., Miklánková, D., Vaňourková, Z., Neckář, J., Kadlecová, M., Kujal, P., Zicha, J., Vaněčková, I. Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats, an experimental non-diabetic model of hypertension. Biomedicine & Pharmacotherapy. 2021, 144(Dec), 112246. https://doi.org/10.1016/j.biopha.2021.112246
IPHYS
IKEM
Dolejší, E., Szánti-Pintér, E., Chetverikov, N., Nelic, D., Randáková, A., Doležal, V., Kudová, E., Jakubík, J. Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptors. Neuropharmacology. 2021, 199(Nov 1), 108798. https://doi.org/10.1016/j.neuropharm.2021.108798
IPHYS
IOCB
Mengr, A., Hrubá, L., Exnerová, A., Holubová, M., Popelová, A., Železná, B., Kuneš, J., Maletínská, L. Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study. Current Alzheimer Research. 2021, 18(8), 607–622. http://dx.doi.org/10.2174/1567205018666210922110652
IPHYS
IOCB
Krijt, J., Sokolová, J., Šilhavý, J., Mlejnek, P., Kubovčiak, J., Liška, F., Malínská, H., Hüttl, M., Marková, I., Křížková, M., Stipanuk, M. H., Křížek, T., Ditroi, T., Nagy, P., Kožich, V., Pravenec, M. High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats. Physiological Research. 2021, 70(5), 687–700. https://doi.org/10.33549%2Fphysiolres.934736
IPHYS
IKEM
Neckář, J., Alánová, P., Olejníčková, V., Papoušek, F., Hejnová, L., Šilhavý, J., Behuliak, M., Bencze, M., Hrdlička, J., Vecka, M., Jarkovská, D., Švíglerová, J., Mistrová, E., Štengl, M., Novotný, J., Ošťádal, B., Pravenec, M., Kolář, F. Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats. Clinical science. 2021, 135(17), 2143–2163. https://doi.org/10.1042/cs20210648
IPHYS
IKEM
Pirník, Z., Kořínková, L., Osacká, J., Železná, B., Kuneš, J., Maletínská, L.. Cholecystokinin System Is Involved in the Anorexigenic Effect of Peripherally Applied Palmitoylated Prolactin-Releasing Peptide in Fasted Mice. Physiological Research. 2021, 70(4), 579–590. https://doi.org/10.33549/physiolres.934694
IPHYS
IOCB
Karnošová, A., Strnadová, V., Holá, L., Železná, B., Kuneš, J., Maletínská, L.. Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10, NPFF-R2 and NPFF-R1 Receptors: In Vitro Study. International Journal of Molecular Sciences. 2021, 22(16), 8904. https://doi.org/10.3390/ijms22168904
IPHYS
IOCB
Dolejší, E., Chetverikov, N., Szánti-Pintér, E., Nelic, D., Randáková, A., Doležal, V., El-Fakahany, E. E., Kudová, E., Jakubík, J. Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors. Biochemical Pharmacology. 2021, 192(Oct), 114699. https://doi.org/10.1016/j.bcp.2021.114699
IPHYS
IOCB
Holubová, K., Chvojková, M., Hrčka Krausová, B., Vyklický, V., Kudová, E., Chodounská, H., Vyklický ml., L., Valeš, K. Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia. Biomolecules. 2021, 11(7), 1026. https://doi.org/10.3390%2Fbiom11071026
IPHYS
IOCB
Kacířová, M., Železná, B., Blažková, M., Holubová, M., Popelová, A., Kuneš, J., Šedivá, B., Maletínská, L.. Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22. Journal of Neuroinflammation. 2021, 18(1), 141. https://doi.org/10.1186/s12974-021-02190-3
IPHYS
IOCB
Boušová, K., Bednárová, L., Zouharová, M., Vetýšková, V., Poštulková, K., Hofbauerová, K., Petrvalská, O., Vaněk, O., Tripsianes, K., Vondrášek, J. The order of PDZ3 and TrpCage in fusion chimeras determines their properties—a biophysical characterization. Protein Science. 2021, 30(8), 1653–1666. https://doi.org/10.1002/pro.4107
IPHYS
IOCB
Husková, Z., Kikerlová, S., Sadowski, J., Alánová, P., Sedláková, L., Papoušek, F., Neckář, J. Increased Endogenous Activity of the Renin-Angiotensin System Reduces Infarct Size in the Rats with Early Angiotensin II-dependent Hypertension which Survive the Acute Ischemia/Reperfusion Injury. Frontiers in Pharmacology. 2021, 12(May 28), 679060. https://doi.org/10.3389/fphar.2021.679060
IPHYS
IKEM
Smejkalová, T., Kořínek, M., Krůšek, J., Hrčka Krausová, B., Candelas Serra, M., Hajduković, D., Kudová, E., Chodounská, H., Vyklický ml., L. Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms. British Journal of Pharmacology. 2021, 178(19), 3888–3904. https://doi.org/10.1111/bph.15529
IPHYS
IOCB
Junková, K., Mirchi, L. F., Chylíková, B., Janků, M., Šilhavý, J., Hüttl, M., Marková, I., Miklánková, D., Včelák, J., Malínská, H., Pravenec, M., Šeda, O., Liška, F. Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation. Nutrients. 2021, 13(5), 1462. https://doi.org/10.3390/nu13051462
IPHYS
IKEM
Uchytilová, E., Špicarová, D., Paleček, J. Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist. International Journal of Molecular Sciences. 2021, 22(7), 3712. https://doi.org/10.3390%2Fijms22073712
IPHYS
IKEM
Pražienková, V., Funda, J., Pirník, Z., Karnošová, A., Hrubá, L., Kořínková, L., Neprašová, B., Janovská, P., Bencze, M., Kadlecová, M., Blahoš, J., Kopecký, J., Železná, B., Kuneš, J., Bardová, K., Maletínská, L. GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis. Gene. 2021, 774(Mar 30), 145427. https://doi.org/10.1016/j.gene.2021.145427
IPHYS
IOCB
Hubálková, P., Ladislav, M., Vyklický, V., Smejkalová, T., Hrčka Krausová, B., Kysilov, B., Krůšek, J., Naimová, Ž., Kořínek, M., Chodounská, H., Kudová, E., Černý, J., Vyklický ml., L. Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity. Journal of Neuroscience. 2021, 41(10), 2119–2134. https://doi.org/10.1523/jneurosci.2654-20.2021
IPHYS
IOCB
Krausová, A., Burešová, P., Sarnová, L., Oyman-Eyrilmez, G., Škarda, J., Wohl, P., Bajer, L., Sticová, E., Bartoňová, L., Pácha, J., Koubková, G., Procházka, J., Sporrer, M., Durrbeck, C., Stehlíková, Zuzana, V., M., Ziolkowska, N., Sedláček, R., Jirák, D., Kverka, M., Wiche, G., Fabry, B., Kořínek, V., Gregor, M. Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal Immunology. 2021, 14(3), 691–702. https://doi.org/10.1038/s41385-021-00380-z
IPHYS
IKEM
Filová, E., Steinerová, M., Trávníčková, M., Knitlová, J., Musílková, J., Eckhardt, A., Hadraba, D., Matějka, R., Pražák, Š., Štěpanovská, J., Kučerová, J., Riedel, T., Brynda, E., Lodererová, A., Honsová, E., Pirk, J., Koňařík, M., Bačáková, L. Accelerated in vitro recellularization of decellularized porcine pericardium for cardiovascular grafts. Biomedical Materials. 2021, 16(2), 025024. https://doi.org/10.1088/1748-605X/abbdbd
IPHYS
IKEM
Honetschlagerová, Z., Gawrys, O., Jíchová, Š., Škaroupková, P., Kikerlová, S., Vaňourková, Z., Husková, Z., Melenovský, V., Kompanowska., Jezierska, E., Sadowski, J., Kolář, F., Novotný, J., Hejnová, L., Kujal, P., Červenka, L. Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula. Kidney & Blood Pressure Research. 2021, 46(1), 95–113. https://doi.org/10.1159/000513071
IPHYS
IKEM
Ošťádal, B., Ošťádalová, I., Szárszoi, O., Netuka, I., Olejníčková, V., Hlaváčková, M. Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults. Canadian Journal of Physiology and Pharmacology. 2021, 99(1), 1–8. https://doi.org/10.1139/cjpp-2020-0310
IPHYS
IKEM
Brejchová, K., Radner, F. P. W., Balas, L., Palůchová, V., Čajka, T., Chodounská, H., Kudová, E., Schratter, M., Schreiber, R., Durand, T., Zechner, R., Kuda, O. Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(2), e2020999118. https://doi.org/10.1073/pnas.2020999118
IPHYS
IOCB

2020

Bardová, K., Funda, J., Pohl, R., Čajka, T., Hensler, M., Kuda, O., Janovská, P., Adamcová, K., Irodenko, I., Leňková, L., Zouhar, P., Horáková, O., Flachs, P., Rossmeisl, M., Colca, J., Kopecký, J. Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/Fatty Acid Cycling in Adipose Tissue. Nutrients. 2020, 12(12), 3737. https://doi.org/10.3390/nu12123737
IPHYS
IOCB
Šilhavý, J., Malínská, H., Hüttl, M., Marková, I., Oliyarnyk, O., Mlejnek, P., Šimáková, M., Liška, F., Kazdová, L., Moravcová, R., Novotný, J., Pravenec, M. Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats. ANTIOXIDANTS. 2020, 9(12), 1179. https://doi.org/10.3390%2Fantiox9121179
IPHYS
IKEM
Kořínková, L., Pražienková, V., Černá, L., Karnošová, A., Železná, B., Kuneš, J., Maletínská, L. Pathophysiology of NAFLD and NASH in Experimental Models: The Role of Food Intake Regulating Peptides. Frontiers in Endocrinology. 2020, 11(Nov 26), 597583. https://doi.org/10.3389%2Ffendo.2020.597583
IPHYS
IOCB
Pavlišová, J., Horáková, O., Kalendová, V., Burešová, J., Bardová, K., Holendová, B., Plecitá-Hlavatá, L., Vacková, Š., Windrichová, J., Topolčan, O., Kopecký, J., Rossmeisl, M. Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice. Food & Function. 2020, 11(11), 9764–9775. https://doi.org/10.1039/D0FO01942A
IPHYS
IKEM
Janovská, P., Melenovský, V., Svobodová, M., Havlenová, T., Kratochvílová, H., Haluzík, M., Hošková, E., Pelikánová, T., Kautzner, J., Monzo, L., Jurcová, I., Adamcová, K., Leňková, L., Burešová, J., Rossmeisl, M., Kuda, O., Čajka, T., Kopecký, J. Dysregulation of epicardial adipose tissue in cachexia due to heart failure: the role of natriuretic peptides and cardiolipin. Journal of Cachexia Sarcopenia and Muscle. 2020, 11(6), 1614–1627. https://doi.org/10.1002/jcsm.12631
IPHYS
IKEM
Kosek, V., Heczková, M., Novák, F., Meisnerová, E., Nováková, O., Zelenka, J., Bechyňská, K., Vrzáčová, N., Suttnar, J., Hlaváčková, A., Danková, H., Bratová, M., Dasková, N., Malínská, H., Oliyarnyk, O., Wohl, P., Bastová, H., Hajslová, J., Cahová, M. The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach. Nutrients. 2020, 12(8), 2351. https://doi.org/10.3390/nu12082351
IPHYS
IKEM
Zmeškalová, A., Popelová, A., Exnerová, A., Železná, B., Kuneš, J., Maletínská, L. Cellular Signaling and Anti-Apoptotic Effects of Prolactin-Releasing Peptide and Its Analog on SH-SY5Y Cells. International Journal of Molecular Sciences. 2020, 21(17), 6343. https://doi.org/10.3390%2Fijms21176343
IPHYS
IOCB
Matějka, R., Koňařík, M., Štěpanovská, J., Lipenský, J., Chlupáč, J., Turek, D., Pražák, Š., Brož, A., Šimůnková, Z., Mrázová, I., Forostyak, S., Kneppo, P., Rosina, J., Bačáková, L., Pirk, J. Bioreactor Processed Stromal Cell Seeding and Cultivation on Decellularized Pericardium Patches for Cardiovascular Use. Applied Sciences-Basel. 2020, 10(16), 5473. https://doi.org/10.3390/app10165473
IPHYS
IKEM
Hrčka Krausová, B., Kysilov, B., Černý, J., Vyklický, V., Smejkalová, T., Ladislav, M., Balík, A., Kořínek, M., Chodounská, H., Kudová, E., Vyklický ml., L. Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor. Journal of Neuroscience. 2020, 40(31), 5922–5936. https://doi.org/10.1523%2FJNEUROSCI.3010-19.2020
IPHYS
IOCB
Sivčev, S., Slavíková, B., Ivetic, M., Knězů, M., Kudová, E., Zemková, H. Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel gating. Journal of Steroid Biochemistry and Molecular Biology. 2020, 202(Sep), 105725. https://doi.org/10.1016/j.jsbmb.2020.105725
IPHYS
IOCB
Mareš, P., Kudová, E., Valeš, K., Kubová, H. Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats. Pharmacological Reports. 2020, 72(6), 1573–1578. https://doi.org/10.1007/s43440-020-00113-2
IPHYS
IOCB
Smolková, K., Špačková, J., Gotvaldová, K., Dvořák, A., Křenková, A., Hubálek, M., Holendová, B., Vítek, L., Ježek, P. SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2. Scientific Reports. 2020, 10(1), 8677. https://doi.org/10.1038/s41598-020-65351-z
IPHYS
IOCB
Chvojková, M., Rambousek, L., Chodounská, H., Kudová, E., Valeš, K. Synthetic structural modifications of neurosteroid pregnanolone sulfate: Assessment of neuroprotective effects in vivo. European Journal of Pharmacology. 2020, 881(Aug 15), 173187. https://doi.org/10.1016/j.ejphar.2020.173187
IPHYS
IOCB
Strnad, Š., Pražienková, V., Holubová, M., Sýkora, D., Cvačka, J., Maletínská, L., Železná, B., Kuneš, J., Vrkoslav, V. Mass spectrometry imaging of free-floating brain sections detects pathological lipid distribution in a mouse model of Alzheimer's-like pathology. Analyst. 2020, 145(13), 4595–4605. https://doi.org/10.1039/D0AN00592D
IPHYS
IOCB
Plecitá-Hlavatá, L., Jabůrek, M., Holendová, B., Tauber, J., Pavluch, V., Berková, Z., Cahová, M., Schröder, K., Brandes, R. P., Siemen, D., Ježek, P. Glucose-Stimulated Insulin Secretion Fundamentally Requires H2O2 Signaling by NADPH Oxidase 4. Diabetes. 2020, 69(7), 1341–1354. https://doi.org/10.2337/db19-1130
IPHYS
IKEM
Kubánek, M., Schimerová, T., Piherová, L., Brodehl, A., Krebsová, A., Ratnavadivel, S., Stanasiuk, C., Hansíková, H., Zeman, J., Paleček, T., Houštěk, J., Drahota, Z., Nůsková, H., Mikešová, J., Zámečník, J., Macek, M. Jr., Ridzoň, P., Malusková, J., Stránecký, V., Melenovský, V., Milting, H., Kmoch, S. Desminopathy: Novel desmin variants, a new cardiac phenotype, and further evidence for secondary mitochondrial dysfunction. Journal of Clinical Medicine. 2020, 9(4):E937. https://doi.org/10.3390/jcm9040937
IPHYS
IKEM

Filová, E., Staňková, Ľ., Eckhardt, A., Svobodová, J., Musílková, J., Pala, J., Hadraba, D., Brynda, E., Koňařík, M., Pirk, J., Bačáková, L. Modification of Human Pericardium by Chemical Crosslinking. Physiological Research. 2020, 69(1), 49–59. https://doi.org/10.33549%2Fphysiolres.934335

IPHYS
IKEM
Kacířová, M., Zmeškalová, A., Kořínková, L., Železná, B., Kuneš, J., Maletínská, L. Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer's disease-like pathology? Clinical science. 2020, 134(5), 547–570. https://doi.org/10.1042/cs20191313
IPHYS
IOCB
Kořínková, L., Holubová, M., Neprašová, B., Hrubá, L., Pražienková, V., Bencze, M., Haluzík, M., Kuneš, J., Maletínská, L., Železná, B. Synergistic effect of leptin and lipidized PrRP on metabolic pathways in ob/ob mice. Journal of Molecular Endocrinology. 2020, 64(2), 77–90. https://doi.org/10.1530/jme-19-0188
IPHYS
IKEM
IOCB
Palůchová, V., Oseeva, M., Březinová, M., Čajka, T., Bardová, K., Adamcová, K., Žáček, P., Brejchová, K., Balas, L., Chodounská, H., Kudová, E., Schreiber, R., Zechner, R., Durand, T., Rossmeisl, M., Abumrad, N. A., Kopecký, J., Kuda, O. Lipokine 5-PAHSA is regulated by adipose triglyceride lipase and primes adipocytes for de novo lipogenesis in mice. Diabetes. 2020, 69(3), 300–312. https://doi.org/10.2337/db19-0494
IPHYS
IOCB
Sládek, M., Röschová, M., Adámková, V., Hamplová, D., Sumová, A. Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe. Scientific Reports. 2020, 10(1), 1419. https://doi.org/10.1038/s41598-020-58413-9
IPHYS
IKEM

2019

Musílková, J., Filová, E., Pala, J., Matějka, R., Hadraba, D., Vondrášek, D., Kaplan, O., Riedel, T., Brynda, E., Kučerová, J., Koňařík, M., Lopot, F., Pirk, J., Bačáková, L. Human decellularized and crosslinked pericardium coated with bioactive molecular assemblies. Biomedical Materials. 2019, 15(1), 015008. https://doi.org/10.1088/1748-605X/ab52db
IPHYS
IKEM
Pšenáková, K., Hexnerová, R., Srb, P., Obšilová, V., Veverka, V., Obšil, T. The redox-active site of thioredoxin is directly involved in apoptosis signal-regulating kinase 1 binding that is modulated by oxidative stress. FEBS Journal. 2019, 287(8), 1626), 1644. https://doi.org/10.1111/febs.15101
IPHYS
IOCB

Tomášová, P., Bugáňová, M., Pelantová, H., Holubová, M., Šedivá, B., Železná, B., Haluzík, M., Maletínská, L., Kuneš, J., Kuzma, M. Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination. Applied Biochemistry and Biotechnology. 2019, 188(1), 165–184. https://doi.org/10.1007/s12010-018-2899-8

IPHYS
IKEM
IOCB

Holubová, M., Hrubá, L., Popelová, A., Bencze, M., Pražienková, V., Gengler, S., Kratochvílová, H., Haluzík, M., Železná, B., Kuneš, J., Hölscher, C., Maletínská, L. Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of β-amyloid pathology. Neuropharmacology. 2019, 144(Jan), 377–387. https://doi.org/10.1016/j.neuropharm.2018.11.002

IPHYS
IKEM
IOCB
Čermáková, M., Pelantová, H., Neprašová, B., Šedivá, B., Maletínská, L., Kuneš, J., Tomášová, P., Železná, B., Kuzma, M. Metabolomic Study of Obesity and Its Treatment with Palmitoylated Prolactin-Releasing Peptide Analog in Spontaneously Hypertensive and Normotensive Rats. Journal of Proteome Research. 2019, 18(4), 1735–1750. https://doi.org/10.1021/acs.jproteome.8b00964
IPHYS
IOCB
Maletínská, L., Popelová, A., Železná, B., Bencze, M., Kuneš, J. The impact of anorexigenic peptides in experimental models of Alzheimer's disease pathology. Journal of Endocrinology. 2019, 240(2), R47–R72. https://doi.org/10.1530/joe-18-0532
IPHYS
IOCB
Pražienková, V., Schirmer, C., Holubová, M., Železná, B., Kuneš, J., Galas, M. C., Maletínská, L. Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons. Journal of Alzheimer's Disease. 2019, 67(4), 1187–1200. https://doi.org/10.3233/jad-180837
IPHYS
IOCB
Pražienková, V., Popelová, A., Kuneš, J., Maletínská, L. Prolactin-Releasing Peptide: Physiological and Pharmacological Properties. International Journal of Molecular Sciences. 2019, 20(21), 5297. https://doi.org/10.3390/ijms20215297
IPHYS
IOCB
Pšenáková, K., Kohoutová, K., Obšilová, V., Ausserlechner, M. J., Veverka, V., Obšil, T. Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics. Cells. 2019, 8(9), 966. https://doi.org/10.3390/cells8090966
IPHYS
IOCB
Sivčev, S., Slavíková, B., Rupert, M., Ivetic, M., Nekardová, M., Kudová, E., Zemková, H. Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating. Journal of Neurochemistry. 2019, 150(1), 28–43. https://doi.org/10.1111/jnc.14718
IPHYS
IOCB
Šmídová, A., Staňková, K., Petrvalská, O., Lazar, J., Sychrová, H., Obšil, T., Zimmermannová, O., Obšilová, V. The activity of Saccharomyces cerevisiae Na+, K+/H+ antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481. Biochimica Et Biophysica Acta-Molecular Cell Research. 2019, 1866(12), 118534. https://doi.org/10.1016/j.bbamcr.2019.118534
IPHYS
IOCB
Šoltésová, M., Elicharová, H., Srb, P., Růžička, M., Janisova, L., Sychrová, H., Lang, J. Nuclear magnetic resonance investigation of water transport through the plasma membrane of various yeast species. FEMS Microbiology Letters. 2019, 366(18), fnz220. https://doi.org/10.1093/femsle/fnz220
IPHYS
IOCB
Beyrand, V., Voeten, D. F. A. E., Bureš, S., Fernandez, V., Janáček, J., Jirák, D., Rauhut, O., Tafforeau, P. Multiphase progenetic development shaped the brain of flying archosaurs. Scientific Reports. 2019, 9(Jul 25), 10807. https://doi.org/10.1038/s41598-019-46959-2
IPHYS
IKEM
Čertíková Chábová, V., Kujal, P., Vaňourková, Z., Škaroupková, P., Sadowski, J., Kompanowska-Jezierska, E., Tesař, V., Hammock, B., Imig, J., Maxová, H., Červenka, L., Vaněčková, I. Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats. Kidney & Blood Pressure Research. 2019, 44(6), 1493–1505. https://doi.org/10.1159/000504137
IPHYS
IKEM
Hrdlička, J., Neckář, J., Papoušek, F., Husková, Z., Kikerlová, S., Vaňourková, Z., Vernerová, Z., Akat, F., Vašinová, J., Hammock, B.D., Hwang, S.H., Imig, J. D., Falck, J. R., Červenka, L., Kolář, F. Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats. Frontiers in Pharmacology. 2019, 10(Mar 1), 159. https://doi.org/10.3389/fphar.2019.00159
IPHYS
IKEM
Janáček, J., Jirák, D. Volume tensor estimation using a virtual line grid: study of a developing pheasant brain. Image Analysis and Stereology. 2019, 38(3), 255–260. https://doi.org/10.5566/ias.1701
IPHYS
IKEM
Janáček, J., Jirák, D. Variance of the isotropic uniform systematic sampling. Image Analysis and Stereology. 2019, 38(3), 261–267. https://doi.org/10.5566/ias.2218
IPHYS
IKEM
Krátký, V., Kikerlová, S., Husková, Z., Sadowski, J., Kolář, F., Červenka, L. Enhanced Renal Vascular Responsiveness to Angiotensin II and Norepinephrine: A Unique Feature of Female Rats with Congestive Heart Failure. Kidney & Blood Pressure Research. 2019, 44(5), 1128–1141. https://doi.org/10.1159/000502379
IPHYS
IKEM
Neckář, J., Khan, M. A. H., Gross, G. J., Cyprová, M., Hrdlička, J., Kvasilová, A., Falck, J. R., Campbell, W. B., Sedláková, L., Škutová, Š., Olejníčková, V., Gregorovičová, M., Sedmera, D., Kolář, F., Imig, J. D. Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. Clinical science. 2019, 133(8), 939–951. https://doi.org/10.1042/cs20180728
IPHYS
IKEM
Řezáčová, L., Hojná, S., Kopkan, L., Rauchová, H., Kadlecová, M., Zicha, J., Vaněčková, I. Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation. Biomedicine & Pharmacotherapy. 2019, 116(Aug), 108996. https://doi.org/10.1016/j.biopha.2019.108996
IPHYS
IKEM
Svoboda, P., Křížová, E., Šestáková, Š., Vápenková, K., Knejzlík, Z., Rimpelová, S., Rayová, D., Volfová, N., Křížová, I., Rumlová, M., Sýkora, D., Kizek, R., Haluzík, M., Zídek, V., Zídková, J., Škop, V. Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth. Journal of Biological Chemistry. 2019, 294(22), 8676–8689. https://doi.org/10.1074/jbc.ra118.003505
IPHYS
IKEM
Vacková, Š., Kikerlová, S., Melenovský, V., Kolář, F., Imig, J. D., Kompanowska-Jezierska, E., Sadowski, J., Červenka, L. Altered Renal Vascular Responsiveness to Vasoactive Agents in Rats with Angiotensin II-Dependent Hypertension and Congestive Heart Failure. Kidney & Blood Pressure Research. 2019, 44(4), 792–809. https://doi.org/10.1159%2F000501688
IPHYS
IKEM
Vaněčková, I., Behuliak, M., Hojná, S., Kopkan, L., Kadlecová, M., Zicha, J. Exaggerated blood pressure response to fasudil or nifedipine in hypertensive Ren-2 transgenic rats: role of altered baroreflex. Hypertension Research. 2019, 42(2), 145–154. https://doi.org/10.1038/s41440-018-0146-x
IPHYS
IKEM
Vaněčková, I., Hojná, S., Vernerová, Z., Kadlecová, M., Rauchová, H., Kompanowska-Jezierska, E., Vaňourková, Z., Červenka, L., Zicha, J. Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ETA Blockade. Frontiers in physiology. 2019, 10(Sep 18), 1145. https://doi.org/10.3389%2Ffphys.2019.01145
IPHYS
IKEM
Zicha, J., Hojná, S., Kopkan, L., Červenka, L., Vaněčková, I. The Absence of Sympathoexcitation During the Development of Hypertension in Cyp1a1 Ren-2 Transgenic Rats. Physiological Research. 2019, 68(2), 329–334. https://doi.org/10.33549/physiolres.934151
IPHYS
IKEM

2018

Popelová, A., Kákonová, A., Hrubá, L., Kuneš, J., Maletínská, L., Železná, B. Potential neuroprotective and anti-apoptotic properties of a long-lasting stable analog of ghrelin: an in vitro study using SH-SY5Y cells. Physiological Research. 2018, 67(2), 339–346. https://doi.org/10.33549/physiolres.933761
IPHYS
IOCB
Kapras, V., Vyklický, V., Buděšínský, M., Císařová, I., Vyklický ml., L., Chodounská, H., Jahn, U. Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor. Organic Letters. 2018, 20(4), 946–949. https://doi.org/10.1021/acs.orglett.7b03838
IPHYS
IOCB
Krausová, B., Slavíková, B., Nekardová, M., Hubálková, P., Vyklický, V., Chodounská, H., Vyklický ml., L., Kudová, E. Positive Modulators of the N-Methyl-D-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters. Journal of Medicinal Chemistry. 2018, 61(10), 4505–4516. https://doi.org/10.1021/acs.jmedchem.8b00255
IPHYS
IOCB
Holubová, M., Blechová, M., Kákonová, A., Kuneš, J., Železná, B., Maletínská, L. In Vitro and In Vivo Characterization of Novel Stable Peptidic Ghrelin Analogs: Beneficial Effects in the Settings of Lipopolysaccharide-Induced Anorexia in Mice. Journal of Pharmacology and Experimental Therapeutics. 2018, 366(3), 422–432. https://doi.org/10.1124/jpet.118.249086
IPHYS
IOCB
Holubová, M., Hrubá, L., Neprašová, B., Majerčíková, Z., Lacinová, Z., Kuneš, J., Maletínská, L., Železná, B. Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice. Journal of Molecular Endocrinology. 2018, 60(2), 85–94. https://doi.org/10.1530/jme-17-0171
IPHYS
IKEM
IOCB
Adla, S. K., Slavíková, B., Chodounská, H., Vyklický, V., Ladislav, M., Hubálková, P., Krausová, B., Smejkalová, T., Nekardová, M., Šmídková, M., Monincová, L., Souček, R., Vyklický ml., L., Kudová, E. Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif. Frontiers in Pharmacology. 2018, 9(Nov 12), 1299. https://doi.org/10.3389/fphar.2018.01299
IPHYS
IOCB
Antošová, Z., Herkommerová, K., Pichová, I., Sychrová, H. Efficient secretion of three fungal laccases from Saccharomyces cerevisiae and their potential for decolorization of textile industry effluent – A comparative study. Biotechnology Progress. 2018, 34(1), 69–80. https://doi.org/10.1002/btpr.2559
IPHYS
IOCB
Boušová, K., Herman, P., Večeř, J., Bednárová, L., Monincová, L., Majer, P., Vyklický ml., L., Vondrášek, J., Teisinger, J. Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus. FEBS Journal. 2018, 285(3), 599–613. https://doi.org/10.1111/febs.14362
IPHYS
IOCB
Herkommerová, K., Dostál, J., Pichová, I. Decolorization and detoxification of textile wastewaters by recombinant Myceliophthora thermophila and Trametes trogii laccases. 3 Biotech. 2018, 8(12), 505. https://doi.org/10.1007%2Fs13205-018-1525-3
IPHYS
IOCB
Jirátová, M., Pospíšilová, A., Rabyk, M., Pařízek, M., Kovář, J., Gálisová, A., Hrubý, M., Jirák, D. Biological characterization of a novel hybrid copolymer carrier system based on glycogen. Drug Delivery and Translational Research. 2018, 8(1), 73–82. https://doi.org/10.1007/s13346-017-0436-x
IPHYS
IKEM
Popelová, A., Pražienková, V., Neprašová, B., Kasperová, B. J., Hrubá, L., Holubová, M., Zemenová, J., Blum, D., Železná, B., Galas, M. C., Kuneš, J., Maletínská, L. Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy. Journal of Alzheimer's Disease. 2018, 62(4), 1725–1736. https://doi.org/10.3233/jad-171041
IPHYS
IOCB
Vyklický, V., Krausová, B., Černý, J., Ladislav, M., Smejkalová, T., Kysilov, B., Kořínek, M., Danačíková, Š., Horák, M., Chodounská, H., Kudová, E., Vyklický ml., L. Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit. Frontiers in Molecular Neuroscience. 2018, 11(Apr 6), 110. https://doi.org/10.3389/fnmol.2018.00110
IPHYS
IOCB
Červenka, L., Husková, Z., Kopkan, L., Kikerlová, S., Sedláková, L., Vaňourková, Z., Alánová, P., Kolář, F., Hammock, B.D., Hwang, S.H., Imig, J. D., Falck, J. R., Sadowski, J., Kompanowska-Jezierska, E., Neckář, J. Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension. Journal of Hypertension. 2018, 36(6), 1326–1341. https://doi.org/10.1097/hjh.0000000000001708
IPHYS
IKEM
Dvořák, J., Švihlík, J., Kybic, J., Radochová, B., Janáček, J., Kukal, J., Borovec, J., Habart, D. Volume estimation from single images: an application to pancreatic islets. Image Analysis and Stereology. 2018, 37(3), 191–204. https://doi.org/10.5566/ias.1869
IPHYS
IKEM
Krátký, V., Kopkan, L., Kikerlová, S., Husková, Z., Táborský, M., Sadowski, J., Kolář, F., Červenka, L. The Role of Renal Vascular Reactivity in the Development of Renal Dysfunction in Compensated and Decompensated Congestive Heart Failure. Kidney & Blood Pressure Research. 2018, 43(6), 1730–1741. https://doi.org/10.1159/000495391
IPHYS
IKEM
Mikulášková, B., Holubová, M., Pražienková, V., Zemenová, J., Hrubá, L., Haluzík, M., Železná, B., Kuneš, J., Maletínská, L. Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study. Nutrition & Diabetes. 2018, 8(Jan 16), 5. https://doi.org/10.1038/s41387-017-0015-8
IPHYS
IKEM
Neckář, J., Hsu, A., Khan, M. A. H., Gross, G. J., Nithipatikom, K., Cyprová, M., Benák, D., Hlaváčková, M., Sotáková-Kašparová, D., Falck, J. R., Sedmera, D., Kolář, F., Imig, J. D. Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3. American Journal of Physiology-Heart and Circulatory Physiology. 2018, 315(5), H1148–H1158. https://doi.org/10.1152/ajpheart.00726.2017
IPHYS
IKEM
Peševski, Ž., Kvasilová, A., Stopková, T., Naňka, O., Drobná Krejčí, E., Buffinton, C., Kočková, R., Eckhardt, A., Sedmera, D. Endocardial Fibroelastosis is Secondary to Hemodynamic Alterations in the Chick Embryonic Model of Hypoplastic Left Heart Syndrome. Developmental Dynamics. 2018, 247(3), 509–520. https://doi.org/10.1002/dvdy.24521
IPHYS
IKEM
Poledne, R., Zicha, J. Human genome evolution and development of cardiovascular risk factors through natural selection. Physiological Research. 2018, 67(2), 155–163. https://doi.org/10.33549/physiolres.933885
IPHYS
IKEM
Pravenec, M., Saba, L. M., Zídek, V., Landa, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Strnad, H., Trnovská, J., Škop, V., Hüttl, M., Marková, I., Oliyarnyk, O., Malínská, H., Kazdová, L., Smith, H., Tabakoff, B. Systems genetic analysis of brown adipose tissue function. Physiological Genomics. 2018, 50(1), 52–66. https://doi.org/10.1152/physiolgenomics.00091.2017
IPHYS
IKEM
Rossmeisl, M., Pavlišová, J., Janovská, P., Kuda, O., Bardová, K., Hansíková, J., Svobodová, M., Oseeva, M., Veleba, J., Kopecký Jr., J., Žáček, P., Fišerová, E., Pelikánová, T., Kopecký, J. Differential modulation of white adipose tissue endocannabinoid levels by n-3 fatty acids in obese mice and type 2 diabetic patients. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2018, 1863(7), 712–725. https://doi.org/10.1016/j.bbalip.2018.03.011
IPHYS
IKEM
Sedláková, L., Kikerlová, S., Husková, Z., Červenková, L., Čertíková Chábová, V., Zicha, J., Falck, J. R., Imig, J. D., Kompanowska-Jezierska, E., Sadowski, J., Krátký, V., Červenka, L., Kopkan, L. 20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats. Bioscience Reports. 2018, 38(5), BSR20171496. https://doi.org/10.1042%2FBSR20171496
IPHYS
IKEM
Straka, F., Schorník, D., Mašín, J., Filová, E., Miřejovský, T., Burdíková, Z., Švindrych, Z., Chlup, H., Horný, L., Daniel, M., Machač, J., Skibová, J., Pirk, J., Bačáková, L. A human pericardium biopolymeric scaffold for autologous heart valve tissue engineering: cellular and extracellular matrix structure and biomechanical properties in comparison with a normal aortic heart valve. Journal of Biomaterial Science Polymer Edition. 2018, 29(6), 599–634. https://doi.org/10.1080/09205063.2018.1429732
IPHYS
IKEM
Šilhavý, J., Krijt, J., Sokolová, J., Zídek, V., Mlejnek, P., Šimáková, M., Škop, V., Trnovská, J., Oliyarnyk, O., Marková, I., Hüttl, M., Malínská, H., Kazdová, L., Liška, F., Kožich, V., Pravenec, M. Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats. Physiological Research. 2018, 67(4), 657–662. https://doi.org/10.33549/physiolres.933932
IPHYS
IKEM
Šilhavý, J., Mlejnek, P., Šimáková, M., Vaněčková, I., Behuliak, M., Kuda, O., Sticová, E., Jirsa, M., Pravenec, M. Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet. Physiological Research. 2018, 67(6), 851–856. https://doi.org/10.33549/physiolres.933951
IPHYS
IKEM
Vaněčková, I., Hojná, S., Kadlecová, M., Vernerová, Z., Kopkan, L., Červenka, L., Zicha, J. Renoprotective Effects of ETA Receptor Antagonists Therapy in Experimental Non-Diabetic Chronic Kidney Disease: Is There Still Hope for the Future? Physiological Research. 2018, 67(Suppl.1), S55–S67. https://doi.org/10.33549/physiolres.933898
IPHYS
IKEM

2017

Bugáňová, M., Pelantová, H., Holubová, M., Šedivá, B., Maletínská, L., Železná, B., Kuneš, J., Kačer, P., Kuzma, M., Haluzík, M. The effects of liraglutide in mice with diet-induced obesity studied by metabolomics. Journal of Endocrinology. 2017, 233(1), 93–104. https://doi.org/10.1530/joe-16-0478
IPHYS
IKEM
IOCB
Pražienková, V., Holubová, M., Pelantová, H., Bugáňová, M., Pirník, Z., Mikulášková, B., Popelová, A., Blechová, M., Haluzík, M., Železná, B., Kuzma, M., Kuneš, J., Maletínská, L. Impact of novel palmitoylated prolactin-releasing peptide analogs on metabolic changes in mice with diet-induced obesity. PLoS ONE. 2017, 12(8), e0183449. https://doi.org/10.1371/journal.pone.0183449
IPHYS
IKEM
IOCB
Adla, S. K., Slavíková, B., Šmídková, M., Tloušťová, E., Svoboda, M., Vyklický, V., Krausová, B., Hubálková, P., Nekardová, M., Holubová, K., Valeš, K., Buděšínský, M., Vyklický ml., L., Chodounská, H., Kudová, E. Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors. Steroids. 2017, 117(Jan), 52–61. https://doi.org/10.1016/j.steroids.2016.08.010
IPHYS
IOCB
Gibalová, A., Steinbachová, L., Hafidh, S., Bláhová, V., Gadiou, Z., Michailidis, C., Müller, K., Pleskot, R., Dupľáková, N., Honys, D. Characterization of pollen-expressed bZIP protein interactions and the role of ATbZIP18 in the male gametophyte. Plant Reproduction. 2017, 30(1), 1–17. https://doi.org/10.1007/s00497-016-0295-5
IPHYS
IOCB
Kao, H. Y., Dvořák, D., Park, E., Kenney, J., Kelemen, E., Fenton, A.A. Phencyclidine Discoordinates Hippocampal Network Activity But Not Place Fields. Journal of Neuroscience. 2017, 37(49), 12031–12049. https://doi.org/10.1523/jneurosci.0630-17.2017
IPHYS
IOCB
Zemenová, J., Sýkora, D., Maletínská, L., Kuneš, J. Lipopeptides as therapeutics: applications and in vivo quantitative analysis. Bioanalysis. 2017, 9(2), 215–230. https://doi.org/10.4155/bio-2016-0206
IPHYS
IOCB
Jirák, D., Janáček, J. Volume of the crocodilian brain and endocast during ontogeny. PLoS ONE. 2017, 12(6), e0178491. https://doi.org/10.1371/journal.pone.0178491
IPHYS
IKEM
Kostiv, U., Rajsiglová, L., Luptáková, D., Pluháček, T., Vannucci, L., Havlíček, V., Engstová, H., Jirák, D., Šlouf, M., Makovický, P., Sedláček, R., Horák, D. Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models. RSC Advances. 2017, 7(73), 45997–46006. https://doi.org/10.1039/C7RA08712H
IPHYS
IKEM
Liška, F., Landa, V., Zídek, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Strnad, H., Trnovská, J., Škop, V., Kazdová, L., Starker, C.G., Voytas, D.F., Izsvák, Z., Mancini, M., Šeda, O., Křen, V., Pravenec, M. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Hypertension. 2017, 69(6), 1084–1091. https://doi.org/10.1161/hypertensionaha.116.08798
IPHYS
IKEM
Lišková, J., Hadraba, D., Filová, E., Koňařík, M., Pirk, J., Jelen, K., Bačáková, L. Valve interstitial cell culture: Production of mature type I collagen and precise detection. Microscopy Research and Technique. 2017, 80(8), 936–942. https://doi.org/10.1002/jemt.22886
IPHYS
IKEM
Melenovský, V., Petrák, J., Mráček, T., Beneš, J., Borlaug, B. A., Nůsková, H., Pluháček, T., Špatenka, J., Kovalčíková, J., Drahota, Z., Kautzner, J., Pirk, J., Houštěk, J. Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. European Journal of Heart Failure. 2017, 19(4), 522–530. https://doi.org/10.1002/ejhf.640
IPHYS
IKEM
Neckář, J., Svatoňová, A., Weissová, R., Drahota, Z., Zajíčková, P., Brabcová, I., Kolář, D., Alánová, P., Vašinová, J., Šilhavý, J., Hlaváčková, M., Tauchmannová, K., Milerová, M., Ošťádal, B., Červenka, L., Žurmanová, J., Kalous, M., Nováková, O., Novotný, J., Pravenec, M., Kolář, F. Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats. Clinical science. 2017, 131(9), 865–881. https://doi.org/10.1042/cs20170083
IPHYS
IKEM
Pravenec, M., Zídek, V., Landa, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Trnovská, J., Škop, V., Marková, I., Malínská, H., Hüttl, M., Kazdová, L., Bardová, K., Tauchmannová, K., Vrbacký, M., Nůsková, H., Mráček, T., Kopecký, J., Houštěk, J. Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Physiological Research. 2017, 66(6), 917–924. https://doi.org/10.33549/physiolres.933811
IPHYS
IKEM
Sedláková, L., Čertíková Chábová, V., Doleželová, Š., Škaroupková, P., Kopkan, L., Husková, Z., Červenková, L., Kikerlová, S., Vaněčková, I., Sadowski, J., Kompanowska-Jezierska, E., Kujal, P., Kramer, H. J., Červenka, L. Renin-angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clinical and Experimental Hypertension. 2017, 39(2), 183–195. https://doi.org/10.1080/10641963.2016.1235184
IPHYS
IKEM
Straka, F., Schorník, D., Mašín, J., Filová, E., Miřejovský, T., Burdíková, Z., Švindrych, Z., Chlup, H., Horný, L., Veselý, J., Pirk, J., Bačáková, L. A New Approach to Heart Valve Tissue Engineering Based on Modifying Autologous Human Pericardium by 3D Cellular Mechanotransduction. Journal of Biomaterials and Tissue Engineering. 2017, 7(7), 527–543. https://doi.org/10.1166/jbt.2017.1598
IPHYS
IKEM
Šeda, O., Liška, F., Pravenec, M., Vernerová, Z., Kazdová, L., Křenová, D., Zídek, V., Šedová, L., Krupková, M., Křen, V. Connexin 50 Mutation Lowers Blood Pressure in Spontaneously Hypertensive Rat. Physiological Research. 2017, 66(1), 15–28. https://doi.org/10.33549/physiolres.933432
IPHYS
IKEM
Špaček, T., Pavluch, V., Alán, L., Capková, N., Engstová, H., Dlasková, A., Berková, Z., Saudek, F., Ježek, P. Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats. Scientific Reports. 2017, 7(Nov 15), 15674. https://doi.org/10.1038/s41598-017-15958-6
IPHYS
IKEM
Trnovská, J., Šilhavý, J., Kuda, O., Landa, V., Zídek, V., Mlejnek, P., Šimáková, M., Strnad, H., Škop, V., Oliyarnyk, O., Kazdová, L., Haluzík, M., Pravenec, M. Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls. PLoS ONE. 2017, 12(6), e0179063. https://doi.org/10.1371/journal.pone.0179063
IPHYS
IKEM

2016

Kuda, O., Březinová, M., Rombaldová, M., Slavíková, B., Pošta, M., Beier, P., Janovská, P., Veleba, J., Kopecký Jr., J., Kudová, E., Pelikánová, T., Kopecký, J. Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. Diabetes. 2016, 65(9), 2580–2590. https://doi.org/10.2337/db16-0385
IPHYS
IKEM
IOCB
Holubová, M., Zemenová, J., Mikulášková, B., Panajotová, V., Stöhr, J., Haluzík, M., Kuneš, J., Železná, B., Maletínská, L. Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats. Journal of Endocrinology. 2016, 229(2), 85–96. https://doi.org/10.1530/joe-15-0519
IPHYS
IOCB
Jirků, M., Lánský, Z., Bednárová, L., Šulc, M., Monincová, L., Majer, P., Vyklický ml., L., Vondrášek, J., Teisinger, J., Boušová, K. The characterization of a novel S100A1 binding site in the N-terminus of TRPM1. International Journal of Biochemistry and Cell Biology. 2016, 78(Sep 2016), 186–193. https://doi.org/10.1016/j.biocel.2016.07.014
IPHYS
IOCB
Kasal, A., Buděšínský, M., Mareš, P., Krištofíková, Z., Leitao, A. J., Sá e Melo, M. L., Silva, M. M. C. Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group? Steroids. 2016, 105(Jan), 12–18. https://doi.org/10.1016/j.steroids.2015.11.007
IPHYS
IOCB
Kuneš, J., Pražienková, V., Popelová, A., Mikulášková, B., Zemenová, J., Maletínská, L. Prolactin-releasing peptide: a new tool for obesity treatment. Journal of Endocrinology. 2016, 230(2), R51–R58. https://doi.org/10.1530/joe-16-0046
IPHYS
IOCB
Mikulášková, B., Zemenová, J., Pirník, Z., Pražienková, V., Bednárová, L., Železná, B., Maletínská, L., Kuneš, J. Effect of palmitoylated prolactin-releasing peptide on food intake and neural activation after different routes of peripheral administration in rats. Peptides. 2016, 75(Jan), 109–117. https://doi.org/10.1016/j.peptides.2015.11.005
IPHYS
IOCB
Mikulášková, B., Maletínská, L., Zicha, J., Kuneš, J. The role of food intake regulating peptides in cardiovascular regulation. Molecular and Cellular Endocrinology. 2016, 436(Nov 15), 78–92. https://doi.org/10.1016/j.mce.2016.07.021
IPHYS
IOCB
Kirubakaran, P., Pfeiferová, L., Boušová, K., Bednárová, L., Obšilová, V., Vondrášek, J. Artificial proteins as allosteric modulators of PDZ3 and SH3 in two-domain constructs: A computational characterization of novel chimeric proteins. Proteins-Structure, Function and Bioinformatics. 2016, 84(10), 1358–1374. https://doi.org/10.1002/prot.25082
IPHYS
IOCB
Pelantová, H., Bugáňová, M., Holubová, M., Šedivá, B., Zemenová, J., Sýkora, D., Kaválková, P., Haluzík, M., Železná, B., Maletínská, L., Kuneš, J., Kuzma, M. Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination. Molecular and Cellular Endocrinology. 2016, 431(C), 88–100. https://doi.org/10.1016/j.mce.2016.05.003
IPHYS
IOCB
Slavíková, B., Chodounská, H., Nekardová, M., Vyklický, V., Ladislav, M., Hubálková, P., Krausová, B., Vyklický ml., L., Kudová, E. Neurosteroid-like Inhibitors of N-Methyl-D-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene. Journal of Medicinal Chemistry. 2016, 59(10), 4724–4739. https://doi.org/10.1021/acs.jmedchem.6b00079
IPHYS
IOCB
Vyklický, V., Smejkalová, T., Krausová, B., Balík, A., Kořínek, M., Borovská, J., Horák, M., Chvojková, M., Kletečková, L., Valeš, K., Černý, J., Nekardová, M., Chodounská, H., Kudová, E., Vyklický ml., L. Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives. Journal of Neuroscience. 2016, 36(7), 2161–2175. https://doi.org/10.1523/JNEUROSCI.3181-15.2016
IPHYS
IOCB
Jíchová, Š., Kopkan, L., Husková, Z., Doleželová, Š., Neckář, J., Kujal, P., Vernerová, Z., Kramer, H. J., Sadowski, J., Kompanowska-Jezierska, E., Reddy, N. R., Falck, J. R., Imig, J. D., Červenka, L. Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. Journal of Hypertension. 2016, 34(10), 2008–2025. https://doi.org/10.1097%2FHJH.0000000000001029
IPHYS
IKEM
Kočková, R., Kačer, P., Pirk, J., Malý, J., Sukupová, L., Sikula, V., Kotrc, M., Barciaková, L., Honsová, E., Malý, M., Kautzner, J., Sedmera, D., Penicka, M. Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy. Circulation Journal. 2016, 80(5), 1202–1209. https://doi.org/10.1253/circj.cj-15-1309
IPHYS
IKEM
Malínská, H., Oliyarnyk, O., Škop, V., Šilhavý, J., Landa, V., Zídek, V., Mlejnek, P., Šimáková, M., Strnad, H., Kazdová, L., Pravenec, M. Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein. PLoS ONE. 2016, 11(3), e0150924. https://doi.org/10.1371%2Fjournal.pone.0150924
IPHYS
IKEM
Pravenec, M., Kožich, V., Krijt, J., Sokolová, J., Zídek, V., Landa, V., Mlejnek, P., Šilhavý, J., Šimáková, M., Škop, V., Trnovská, J., Kazdová, L., Kajiya, T., Wang, J. M., Kurtz, T. W. Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome. Hypertension. 2016, 67(2), 335–341. https://doi.org/10.1161/hypertensionaha.115.06158
IPHYS
IKEM
Pravenec, M., Mlejnek, P., Zídek, V., Landa, V., Šimáková, M., Šilhavý, J., Strnad, H., Eigner, S., Eigner-Henke, K., Škop, V., Malínská, H., Trnovská, J., Kazdová, L., Drahota, Z., Mráček, T., Houštěk, J. Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue. Physiological Genomics. 2016, 48(6), 420–427. https://doi.org/10.1152/physiolgenomics.00122.2015
IPHYS
IKEM
Rambousek, L., Kletečková, L., Kubesová, A., Jirák, D., Valeš, K., Fritschy, J.M. Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits. Neuropharmacology. 2016, 105(Jun), 594–606. https://doi.org/10.1016/j.neuropharm.2016.02.035
IPHYS
IKEM
Sedmera, D., Neckář, J., Beneš Jr., J., Pospíšilová, J., Petrák, J., Sedláček, K., Melenovský, V. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload. Frontiers in physiology. 2016, 7(Aug 25), 367. https://doi.org/10.3389/fphys.2016.00367
IPHYS
IKEM
Šedová, L., Pravenec, M., Křenová, D., Kazdová, L., Zídek, V., Krupková, M., Liška, F., Křen, V., Šeda, O. Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model. PLoS ONE. 2016, 11(3), e0152708. https://doi.org/10.1371%2Fjournal.pone.0152708
IPHYS
IKEM
Škop, V., Trnovská, J., Oliyarnyk, O., Marková, I., Malínská, H., Kazdová, L., Zídek, V., Landa, V., Mlejnek, P., Šimáková, M., Kůdela, M., Pravenec, M., Šilhavý, J. Hepatotoxic effects of fenofibrate in spontaneously hypertensive rats expressing human C-reactive protein. Physiological Research. 2016, 65(6), 891–899. https://doi.org/10.33549/physiolres.933304
IPHYS
IKEM

2015

Boušová, K., Jirků, M., Bumba, L., Bednárová, L., Šulc, M., Franěk, M., Vyklický ml., L., Vondrášek, J., Teisinger, J. PIP2 and PIP3 interact with N-terminus region of TRPM4 channel. Biophysical Chemistry. 2015, 205(Oct 2015), 24–32. https://doi.org/10.1016/j.bpc.2015.06.004
IPHYS
IOCB
Jirků, M., Bumba, L., Bednárová, L., Kubala, M., Šulc, M., Franěk, M., Vyklický ml., L., Vondrášek, J., Teisinger, J., Boušová, K. Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel. Biophysical Chemistry. 2015, 207(Dec), 135–142. https://doi.org/10.1016/j.bpc.2015.10.005
IPHYS
IOCB
Kudová, E., Chodounská, H., Slavíková, B., Buděšínský, M., Nekardová, M., Vyklický, V., Krausová, B., Švehla, P., Vyklický ml., L. A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications. Journal of Medicinal Chemistry. 2015, 58(15), 5950–5966. https://doi.org/10.1021/acs.jmedchem.5b00570
IPHYS
IOCB
Kuneš, J., Vaněčková, I., Mikulášková, B., Behuliak, M., Maletínská, L., Zicha, J. Epigenetics and a new look on metabolic syndrome. Physiological Research. 2015, 64(5), 611–620. https://doi.org/10.33549/physiolres.933174
IPHYS
IOCB
Maletínská, L., Nagelová, V., Tichá, A., Zemenová, J., Pirník, Z., Holubová, M., Špolcová, A., Mikulášková, B., Blechová, M., Sýkora, D., Lacinová, Z., Haluzík, M., Železná, B., Kuneš, J. Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration. International Journal of Obesity. 2015, 39(6), 986–993. https://doi.org/10.1038/ijo.2015.28
IPHYS
IOCB
Vyklický, V., Krausová, B., Černý, J., Balík, A., Zápotocký, M., Novotný, M., Lichnerová, K., Smejkalová, T., Kaniaková, M., Kořínek, M., Petrovič, M., Kačer, P., Horák, M., Chodounská, H., Vyklický ml., L. Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule. Scientific Reports. 2015, 5(Jun 18), 10935. https://doi.org/10.1038/srep10935
IPHYS
IOCB
Alán, L., Olejár, T., Cahová, M., Zelenka, J., Berková, Z., Smětáková, M., Saudek, F., Matěj, R., Ježek, P. Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats. Journal of Diabetes Research. 2015, 2015(2015), 385395. https://doi.org/10.1155%2F2015%2F385395
IPHYS
IKEM
Alánová, P., Husková, Z., Kopkan, L., Sporková, A., Jíchová, Š., Neckář, J., Imig, J. D., Klevstig, M., Kolář, F., Reddy, N. R., Falck, J. R., Sadowski, J., Nishiyama, A., Kramer, H. J., Melenovský, V., Červenková, L., Kujal, P., Vernerová, Z., Červenka, L. Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats. Vascular Pharmacology. 2015, 73(Oct 2015), 45–56. https://doi.org/10.1016/j.vph.2015.08.013
IPHYS
IKEM
Cahová, M., Chrastina, P., Hansíková, H., Drahota, Z., Trnovská, J., Škop, V., Spáčilová, J., Malínská, H., Oliyarnyk, O., Papáčková, Z., Páleníčková, E., Kazdová, L. Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats. Applied Physiology Nutrition and Metabolism-Physiologie appliquee nutrition et metabolisme. 2015, 40(3), 280–291. https://doi.org/10.1139/apnm-2014-0163
IPHYS
IKEM
Cahová, M., Páleníčková, E., Danková, H., Sticová, E., Burian, M., Drahota, Z., Červinková, Z., Kučera, O., Gladkova, C., Stopka, P., Křížová, J., Papáčková, Z., Oliyarnyk, O., Kazdová, L. Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2015, 309(2), G100–G111. https://doi.org/10.1152/ajpgi.00329.2014
IPHYS
IKEM
Chytilová, A., Borchert, G. H., Mandíková-Alánová, P., Hlaváčková, M., Kopkan, L., Khan, M. A. H., Imig, J. D., Kolář, F., Neckář, J. Tumour necrosis factor-α contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia. Acta Physiologica. 2015, 241(1), 97–108. https://doi.org/10.1111/apha.12489
IPHYS
IKEM
Jirák, D., Janáček, J., Kear, B. P. A combined MR and CT study for precise quantitative analysis of the avian brain. Scientific Reports. 2015, 5(Oct 30), 16002. https://doi.org/10.1038/srep16002
IPHYS
IKEM
Trnovská, J., Šilhavý, J., Zídek, V., Šimáková, M., Mlejnek, P., Landa, V., Eigner, S., Eigner-Henke, K., Škop, V., Oliyarnyk, O., Kazdová, L., Mráček, T., Houštěk, J., Pravenec, M. Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat. Physiological Research. 2015, 64(1), 51–60. https://doi.org/10.33549/physiolres.932823
IPHYS
IKEM
Veleba, J., Kopecký Jr., J., Janovská, P., Kuda, O., Horáková, O., Malínská, H., Kazdová, L., Oliyarnyk, O., Škop, V., Trnovská, J., Hájek, M., Škoch, A., Flachs, P., Bardová, K., Rossmeisl, M., Olza, J., de Castro, S. G., Calder, P. C., Gardlo, A., Fišerová, E., Jensen, J., Bryhn, M., Kopecký, J., Pelikánová, T. Combined intervention with pioglitazone and n-3 fatty acids in metformin-treated type 2 diabetic patients: improvement of lipid metabolism. Nutrition & Metabolism. 2015, 12(Dec 2), 52. https://doi.org/10.1186%2Fs12986-015-0047-9
IPHYS
IKEM

Sedmera, D., Kočková, R., Vostárek, F., Raddatz, E. Arrhythmias in the developing heart. Acta Physiologica. 2015, 213(2), 303–320. https://doi.org/10.1111/apha.12418

IPHYS
IKEM